| Literature DB >> 17038343 |
Matthew N Bainbridge1, René L Warren, An He, Mikhail Bilenky, A Gordon Robertson, Steven J M Jones.
Abstract
Low-coverage genomes (LCGs) are becoming an increasingly important source of data for phylogenetic studies. However, assembly of these genomes is time consuming, difficult and lags behind sequence generation. THOR is a fast, stringent application for targeted reconstruction of sequence orthologs in unassembled LCGs. Using a 4x coverage set of mouse whole-genome sequence reads, THOR could partially or completely reconstruct 416/1000 human promoter ortholog regions in approximately 7.3 min/promoter. THOR's reconstruction rate improves markedly with both higher-coverage, and less divergent target species.Entities:
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Year: 2006 PMID： 17038343 DOI： 10.1093/bioinformatics/btl513
Source DB: PubMed Journal: Bioinformatics ISSN： 1367-4803 Impact factor: 6.937