Literature DB >> 17036370

The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide.

Víctor M Sánchez-Pedregal1, Karel Kubicek, Jens Meiler, Isabelle Lyothier, Ian Paterson, Teresa Carlomagno.   

Abstract

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Year:  2006        PMID： 17036370     DOI： 10.1002/anie.200602793

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  12 in total

1.  Cyclostreptin derivatives specifically target cellular tubulin and further map the paclitaxel site.

Authors:  Enrique Calvo; Isabel Barasoain; Ruth Matesanz; Benet Pera; Emilio Camafeita; Oriol Pineda; Ernest Hamel; Christopher D Vanderwal; José Manuel Andreu; Juan A López; José Fernando Díaz
Journal:  Biochemistry       Date:  2011-12-30       Impact factor: 3.162

2.  Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.

Authors:  Jessica J Field; Benet Pera; Enrique Calvo; Angeles Canales; Didier Zurwerra; Chiara Trigili; Javier Rodríguez-Salarichs; Ruth Matesanz; Arun Kanakkanthara; St John Wakefield; A Jonathan Singh; Jesús Jiménez-Barbero; Peter Northcote; John H Miller; Juan Antonio López; Ernest Hamel; Isabel Barasoain; Karl-Heinz Altmann; José Fernando Díaz
Journal:  Chem Biol       Date:  2012-06-22

Review 3.  The Lithistida: important sources of compounds useful in biomedical research.

Authors:  Amy E Wright
Journal:  Curr Opin Biotechnol       Date:  2010-12       Impact factor: 9.740

Review 4.  Conformation-activity relationships of polyketide natural products.

Authors:  Erik M Larsen; Matthew R Wilson; Richard E Taylor
Journal:  Nat Prod Rep       Date:  2015-08       Impact factor: 13.423

5.  MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications.

Authors:  Kurt R Brunden; Nicola M Gardner; Michael J James; Yuemang Yao; John Q Trojanowski; Virginia M-Y Lee; Ian Paterson; Carlo Ballatore; Amos B Smith
Journal:  ACS Med Chem Lett       Date:  2013-07-23       Impact factor: 4.345

Review 6.  Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Authors:  Carlo Ballatore; Kurt R Brunden; Donna M Huryn; John Q Trojanowski; Virginia M-Y Lee; Amos B Smith
Journal:  J Med Chem       Date:  2012-09-28       Impact factor: 7.446

7.  Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.

Authors:  Jun Qi; Adam R Blanden; Susan Bane; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2011-07-02       Impact factor: 3.641

8.  Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.

Authors:  Ian Paterson; Guy J Naylor; Nicola M Gardner; Esther Guzmán; Amy E Wright
Journal:  Chem Asian J       Date:  2010-10-28

9.  Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity.

Authors:  Amos B Smith; Keizo Sugasawa; Onur Atasoylu; Chia-Ping Huang Yang; Susan Band Horwitz
Journal:  J Med Chem       Date:  2011-08-26       Impact factor: 7.446

10.  Structural Basis of Microtubule Stabilization by Discodermolide.

Authors:  Andrea E Prota; Katja Bargsten; Mariano Redondo-Horcajo; Amos B Smith; Chia-Ping H Yang; Hayley M McDaid; Ian Paterson; Susan B Horwitz; José Fernando Díaz; Michel O Steinmetz
Journal:  Chembiochem       Date:  2017-03-27       Impact factor: 3.164
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