Literature DB >> 17036110

Synthesis of bisindolylmaleimides related to GF109203x and their efficient conversion to the bioactive indolocarbazoles.

Sudipta Roy1, Alan Eastman, Gordon W Gribble.   

Abstract

From a structure-activity relationship perspective, the new indolocarbazoles 11 and 12 have been synthesized and evaluated biologically as novel Chk1 inhibitors. Compounds 11 and 12 were synthesized in high yield from indole via bisindolylmaleimides 18 and 24.

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Year:  2006        PMID: 17036110     DOI: 10.1039/b607504e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  2 in total

1.  Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells.

Authors:  Martyn Inman; Andrea Visconti; Chao Yan; David Siegel; David Ross; Christopher J Moody
Journal:  Org Biomol Chem       Date:  2014-07-21       Impact factor: 3.876

Review 2.  Marine pyrrolocarbazoles and analogues: synthesis and kinase inhibition.

Authors:  Sébastien Deslandes; Stefan Chassaing; Evelyne Delfourne
Journal:  Mar Drugs       Date:  2009-12-01       Impact factor: 5.118

  2 in total

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