| Literature DB >> 17035101 |
Ju-Suk Nam1, Taryn J Turcotte, Jeong Kyo Yoon.
Abstract
R-spondins (Rspo) are a recently discovered secretory protein family with four members in human and mouse. We and others demonstrated that R-spondins can activate canonical Wnt signaling and beta-catenin-dependent gene expression. Our study further demonstrated that R-spondins are novel ligands for the Frizzled8 and LRP6 (LDL-receptor-related protein 6) receptors. To gain insight into their biological functions, the RNA expression pattern of the mouse R-spondin family genes was analyzed during mouse development. Our study shows that R-spondin gene transcripts are widely expressed with distinct patterns in mouse at different developmental stages.Entities:
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Year: 2006 PMID： 17035101 DOI： 10.1016/j.modgep.2006.08.006
Source DB: PubMed Journal: Gene Expr Patterns ISSN： 1567-133X Impact factor: 1.224