| Literature DB >> 17034993 |
Susan J Howard1, Ian Webster, Caroline B Moore, Rebecca E Gardiner, Steven Park, David S Perlin, David W Denning.
Abstract
Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole. A novel mutation (G138C) in the target gene (cyp51A) encoding 14alpha-demethylase was detected. The patient had some response to intravenous caspofungin, which he received six times weekly, without the development of resistance over 9 months.Entities:
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Year: 2006 PMID： 17034993 DOI： 10.1016/j.ijantimicag.2006.08.017
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283