A systematic analysis of lineage-specific evolution in metabolic pathways.

In a search for the lineage-specific evolution of pathways between human, chimpanzee, mouse, and rat, orthologous gene families were generated from genome sequences. For each family, a model-based ratio of nonsynonymous to synonymous nucleotide substitution rates was calculated. Where the free-ratio model of individual ratios on each branch was supported, these families were mapped to two databases of metabolic pathways (KEGG and BioCyc) and the lineage-specific evolution of pathways was evaluated. The most similar pathway evolution was seen between mouse and rat, while the evolutionary pattern between human and chimpanzee was less correlated. Individual pathways in the human lineage were observed to evolve in a faster, lineage-specific manner, including the pathway involving arachidonic acid metabolism (identified through the KEGG analysis) and pyrimidine metabolism (identified through both analyses).