| Literature DB >> 17034149 |
Neeraj Mahindroo1, Yi-Hui Peng, Chia-Hui Lin, Uan-Kang Tan, Ekambaranellore Prakash, Tzu-Wen Lien, I-Lin Lu, Hong-Jen Lee, John Tsu-An Hsu, Xin Chen, Chun-Chen Liao, Ping-Chiang Lyu, Yu-Sheng Chao, Su-Ying Wu, Hsing-Pang Hsieh.
Abstract
Type 2 diabetes has rapidly reached an epidemic proportion becoming a major threat to global public health. PPAR agonists have emerged as a leading class of oral antidiabetic drugs. We report a structure biology analysis of novel indole-based PPAR agonists to explain the structure-activity relationships and present a critical analysis of reasons for change in selectivity with change in the orientation of the same scaffolds. The results would be helpful in designing novel PPAR agonists.Entities:
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Year: 2006 PMID： 17034149 DOI： 10.1021/jm060663c
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446