Literature DB >> 17034122

Configurationally restricted bismacrocyclic CXCR4 receptor antagonists.

Gina C Valks1, Graeme McRobbie, Elizabeth A Lewis, Timothy J Hubin, Tina M Hunter, Peter J Sadler, Christophe Pannecouque, Erik De Clercq, Stephen J Archibald.   

Abstract

A zinc(II) containing configurationally restricted analogue of bismacrocyclic cyclam-type CXCR4 chemokine receptor antagonists has been synthesized and shown to adopt only one configuration in solution. The single crystal X-ray structure reveals favorable binding to acetate via a bidentate chelation that can be related to the proposed interaction with aspartate on the receptor protein surface. The zinc(II) complex is highly active against HIV infection in vitro.

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Year:  2006        PMID： 17034122     DOI： 10.1021/jm0607810

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  13 in total

1.  Synthesis and antimalarial activity of metal complexes of cross-bridged tetraazamacrocyclic ligands.

Authors:  Timothy J Hubin; Prince N-A Amoyaw; Kimberly D Roewe; Natalie C Simpson; Randall D Maples; TaRynn N Carder Freeman; Amy N Cain; Justin G Le; Stephen J Archibald; Shabana I Khan; Babu L Tekwani; M O Faruk Khan
Journal:  Bioorg Med Chem       Date:  2014-05-11       Impact factor: 3.641

2.  Tetraazamacrocyclic derivatives and their metal complexes as antileishmanial leads.

Authors:  Timothy J Hubin; Ashlie N Walker; Dustin J Davilla; TaRynn N Carder Freeman; Brittany M Epley; Travis R Hasley; Prince N A Amoyaw; Surendra Jain; Stephen J Archibald; Timothy J Prior; Jeanette A Krause; Allen G Oliver; Babu L Tekwani; M Omar F Khan
Journal:  Polyhedron       Date:  2019-02-23       Impact factor: 3.052

3.  Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles.

Authors:  Amy N Cain; TaRynn N Carder Freeman; Kimberly D Roewe; David L Cockriel; Travis R Hasley; Randall D Maples; Elisabeth M A Allbritton; Thomas D'Huys; Tom van Loy; Benjamin P Burke; Timothy J Prior; Dominique Schols; Stephen J Archibald; Timothy J Hubin
Journal:  Dalton Trans       Date:  2019-02-19       Impact factor: 4.390

4.  Binding optimization through coordination chemistry: CXCR4 chemokine receptor antagonists from ultrarigid metal complexes.

Authors:  Abid Khan; Gary Nicholson; John Greenman; Leigh Madden; Graeme McRobbie; Christophe Pannecouque; Erik De Clercq; Robert Ullom; Danny L Maples; Randall D Maples; Jon D Silversides; Timothy J Hubin; Stephen J Archibald
Journal:  J Am Chem Soc       Date:  2009-03-18       Impact factor: 15.419

5.  Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.

Authors:  Randall D Maples; Amy N Cain; Benjamin P Burke; Jon D Silversides; Ryan E Mewis; Thomas D'huys; Dominique Schols; Douglas P Linder; Stephen J Archibald; Timothy J Hubin
Journal:  Chemistry       Date:  2016-07-26       Impact factor: 5.236

6.  Phospholipids showing complex bilayer phase transitions. II. Four sulfur-containing phosphatidylcholines.

Authors:  J Hajdu; J M Sturtevant
Journal:  Chem Phys Lipids       Date:  1990-09       Impact factor: 3.329

7.  Oxovanadium(IV) cyclam and bicyclam complexes: potential CXCR4 receptor antagonists.

Authors:  Allison Ross; Dinesh C Soares; Danielle Covelli; Christophe Pannecouque; Laura Budd; Anna Collins; Neil Robertson; Simon Parsons; Erik De Clercq; Pierre Kennepohl; Peter J Sadler
Journal:  Inorg Chem       Date:  2010-02-01       Impact factor: 5.165

8.  Discovery of Antischistosomal Drug Leads Based on Tetraazamacrocyclic Derivatives and Their Metal Complexes.

Authors:  M O Faruk Khan; Jennifer Keiser; P N A Amoyaw; Mohammad F Hossain; Mireille Vargas; Justin G Le; Natalie C Simpson; Kimberly D Roewe; TaRynn N Carder Freeman; Travis R Hasley; Randall D Maples; Stephen J Archibald; Timothy J Hubin
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

9.  64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist.

Authors:  Benjamin P Burke; Cecilia S Miranda; Rhiannon E Lee; Isaline Renard; Shubhanchi Nigam; Gonçalo S Clemente; Thomas D'Huys; Torsten Ruest; Juozas Domarkas; James A Thompson; Timothy J Hubin; Dominique Schols; Christopher J Cawthorne; Stephen J Archibald
Journal:  J Nucl Med       Date:  2019-06-14       Impact factor: 11.082

10.  Bridged cyclams as imaging agents for chemokine receptor 4 (CXCR4).

Authors:  Lauren E Woodard; Ravindra A De Silva; Babak Behnam Azad; Ala Lisok; Mrudula Pullambhatla; Wojciech G Lesniak; Ronnie C Mease; Martin G Pomper; Sridhar Nimmagadda
Journal:  Nucl Med Biol       Date:  2014-04-21       Impact factor: 2.408
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