OBJECTIVE: This nested case-control study evaluated the association between depression and pesticide exposure among women. METHODS: The study population included 29,074 female spouses of private pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Cases were women who had physician-diagnosed depression requiring medication. Lifetime pesticide use was categorized as never mixed/applied pesticides, low exposure (up to 225 days), high exposure (>225 days), and a history of diagnosed pesticide poisoning. RESULTS: After adjustment for state, age, race, off-farm work, alcohol, cigarette smoking, physician visits, and solvent exposure, depression was significantly associated with a history of pesticide poisoning (odds ratio [OR] = 3.26; 95% confidence interval [CI] = 1.72-6.19) but not low (OR = 1.09; CI = 0.91-1.31) or high (OR = 1.09; 95% CI = 0.91-1.31) cumulative pesticide exposure. CONCLUSION: Pesticide poisoning may contribute to risk of depression.
OBJECTIVE: This nested case-control study evaluated the association between depression and pesticide exposure among women. METHODS: The study population included 29,074 female spouses of private pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Cases were women who had physician-diagnosed depression requiring medication. Lifetime pesticide use was categorized as never mixed/applied pesticides, low exposure (up to 225 days), high exposure (>225 days), and a history of diagnosed pesticide poisoning. RESULTS: After adjustment for state, age, race, off-farm work, alcohol, cigarette smoking, physician visits, and solvent exposure, depression was significantly associated with a history of pesticide poisoning (odds ratio [OR] = 3.26; 95% confidence interval [CI] = 1.72-6.19) but not low (OR = 1.09; CI = 0.91-1.31) or high (OR = 1.09; 95% CI = 0.91-1.31) cumulative pesticide exposure. CONCLUSION: Pesticide poisoning may contribute to risk of depression.
Authors: A Blair; D Sandler; K Thomas; J A Hoppin; F Kamel; J Coble; W J Lee; J Rusiecki; C Knott; M Dosemeci; C F Lynch; J Lubin; M Alavanja Journal: J Agric Saf Health Date: 2005-05
Authors: Jose R Suarez-Lopez; Naomi Hood; José Suárez-Torres; Sheila Gahagan; Megan R Gunnar; Dolores López-Paredes Journal: Int J Hyg Environ Health Date: 2019-06-13 Impact factor: 5.840
Authors: John D Beard; Jane A Hoppin; Marie Richards; Michael C R Alavanja; Aaron Blair; Dale P Sandler; Freya Kamel Journal: Environ Res Date: 2013-08-02 Impact factor: 6.498