Literature DB >> 17033254

Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat.

E Bresciani1, D Rapetti, F Donà, I Bulgarelli, L Tamiazzo, V Locatelli, A Torsello.   

Abstract

Obestatin is a recently discovered 23 amino acids peptide derived from the ghrelin gene. As opposed to ghrelin, obestatin was shown to inhibit food intake in mice. The aims of this research were to study the effects of acute obestatin treatment on feeding behavior in the rat and its effects on GH and corticosterone secretion. Our results demonstrate that in young-adult male rats, obestatin effectively blunts the hunger caused by short-term starvation. Obestatin did not modify GH secretion in 10-day-old rats and did not antagonize the GH-releasing effects of hexarelin. Moreover, obestatin administration had no effects on spontaneous corticosterone secretion. In conclusion, these data demonstrate that in young-adult male rats the newly discovered obestatin can inhibit feeding but does not modify GH and corticosterone release in infant rats.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17033254     DOI： 10.1007/BF03344175

Source DB:  PubMed          Journal:  J Endocrinol Invest        ISSN： 0391-4097            Impact factor:   4.256


  14 in total

Review 1.  Amygdala subsystems and control of feeding behavior by learned cues.

Authors:  Gorica D Petrovich; Michela Gallagher
Journal:  Ann N Y Acad Sci       Date:  2003-04       Impact factor: 5.691

2.  The orexigenic effect of peripheral ghrelin differs between rats of different age and with different baseline food intake, and it may in part be mediated by the area postrema.

Authors:  S Gilg; T A Lutz
Journal:  Physiol Behav       Date:  2005-12-13

3.  Obestatin alters sleep in rats.

Authors:  Eva Szentirmai; James M Krueger
Journal:  Neurosci Lett       Date:  2006-06-23       Impact factor: 3.046

Review 4.  Ghrelin, hypothalamus-pituitary-adrenal (HPA) axis and Cushing's syndrome.

Authors:  Roberta Giordano; Andreea Picu; Fabio Broglio; Lorenza Bonelli; Matteo Baldi; Rita Berardelli; Ezio Ghigo; Emanuela Arvat
Journal:  Pituitary       Date:  2004       Impact factor: 4.107

5.  Ghrelin enhances appetite and increases food intake in humans.

Authors:  A M Wren; L J Seal; M A Cohen; A E Brynes; G S Frost; K G Murphy; W S Dhillo; M A Ghatei; S R Bloom
Journal:  J Clin Endocrinol Metab       Date:  2001-12       Impact factor: 5.958

6.  Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake.

Authors:  Jian V Zhang; Pei-Gen Ren; Orna Avsian-Kretchmer; Ching-Wei Luo; Rami Rauch; Cynthia Klein; Aaron J W Hsueh
Journal:  Science       Date:  2005-11-11       Impact factor: 47.728

7.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

Authors:  M Kojima; H Hosoda; Y Date; M Nakazato; H Matsuo; K Kangawa
Journal:  Nature       Date:  1999-12-09       Impact factor: 49.962

8.  Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release.

Authors:  A Torsello; M Luoni; F Schweiger; R Grilli; M Guidi; E Bresciani; R Deghenghi; E E Müller; V Locatelli
Journal:  Eur J Pharmacol       Date:  1998-11-06       Impact factor: 4.432

9.  GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats.

Authors:  R Deghenghi; M M Cananzi; A Torsello; C Battisti; E E Muller; V Locatelli
Journal:  Life Sci       Date:  1994       Impact factor: 5.037

Review 10.  Sleep and endocrinology.

Authors:  A Steiger
Journal:  J Intern Med       Date:  2003-07       Impact factor: 8.989
View more
  30 in total

1.  Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice.

Authors:  Xiaojun Ma; Yuezhen Lin; Ligen Lin; Guijun Qin; Fred A Pereira; Morey W Haymond; Nancy F Butte; Yuxiang Sun
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-06-05       Impact factor: 4.310

2.  Circulating obestatin levels in normal and Type 2 diabetic subjects.

Authors:  D H St-Pierre; F Settanni; I Olivetti; E Gramaglia; M Tomelini; R Granata; F Prodam; A Benso; E Ghigo; F Broglio
Journal:  J Endocrinol Invest       Date:  2010-05-05       Impact factor: 4.256

3.  Obestatin partially affects ghrelin stimulation of food intake and growth hormone secretion in rodents.

Authors:  Philippe Zizzari; Romaine Longchamps; Jacques Epelbaum; Marie Thérèse Bluet-Pajot
Journal:  Endocrinology       Date:  2007-01-04       Impact factor: 4.736

4.  Intracerebroventricular acute and chronic administration of obestatin minimally affect food intake but not weight gain in the rat.

Authors:  V Sibilia; E Bresciani; N Lattuada; D Rapetti; V Locatelli; V De Luca; F Donà; C Netti; A Torsello; F Guidobono
Journal:  J Endocrinol Invest       Date:  2006-12       Impact factor: 4.256

Review 5.  Central dysregulations in the control of energy homeostasis and endocrine alterations in anorexia and bulimia nervosa.

Authors:  A Torsello; F Brambilla; L Tamiazzo; I Bulgarelli; D Rapetti; E Bresciani; V Locatelli
Journal:  J Endocrinol Invest       Date:  2007-12       Impact factor: 4.256

6.  The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice.

Authors:  Eva Szentirmai; Levente Kapás; Yuxiang Sun; Roy G Smith; James M Krueger
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-04       Impact factor: 11.205

7.  Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats.

Authors:  Jun Wang; Chen Chen; Rui-Yuan Wang
Journal:  Endocrine       Date:  2008-04-04       Impact factor: 3.633

8.  Effect of peripheral obestatin on food intake and gastric emptying in ghrelin-knockout mice.

Authors:  I Depoortere; T Thijs; D Moechars; B De Smet; L Ver Donck; T L Peeters
Journal:  Br J Pharmacol       Date:  2008-01-21       Impact factor: 8.739

9.  Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents.

Authors:  Peter Kobelt; Anna-Sophia Wisser; Andreas Stengel; Miriam Goebel; Norbert Bannert; Guillaume Gourcerol; Tobias Inhoff; Steffen Noetzel; Bertram Wiedenmann; Burghard F Klapp; Yvette Taché; Hubert Mönnikes
Journal:  Peptides       Date:  2008-02-07       Impact factor: 3.750

10.  Eradication of Helicobacter pylori increases ghrelin mRNA expression in the gastric mucosa.

Authors:  Eon Sook Lee; Yeong Sook Yoon; Cheol-Young Park; Han-Seong Kim; Tae Hyun Um; Hyun Wook Baik; Eun Jeong Jang; Sangyeoup Lee; Hee Soon Park; Sang Woo Oh
Journal:  J Korean Med Sci       Date:  2010-01-22       Impact factor: 2.153
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.