BACKGROUND: The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected. METHODS: We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS: Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS: These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families. (c) 2006 Wiley-Liss, Inc.
BACKGROUND: The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected. METHODS: We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped. RESULTS: Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12. CONCLUSIONS: These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families. (c) 2006 Wiley-Liss, Inc.
Authors: Claudia L Hilton; Robert T Fitzgerald; Kelley M Jackson; Rolanda A Maxim; Christopher C Bosworth; Paul T Shattuck; Daniel H Geschwind; John N Constantino Journal: J Autism Dev Disord Date: 2010-05
Authors: Nicola J Camp; Lisa A Cannon-Albright; James M Farnham; Agnes B Baffoe-Bonnie; Asha George; Isaac Powell; Joan E Bailey-Wilson; John D Carpten; Graham G Giles; John L Hopper; Gianluca Severi; Dallas R English; William D Foulkes; Lovise Maehle; Pal Moller; Ros Eeles; Douglas Easton; Michael D Badzioch; Alice S Whittemore; Ingrid Oakley-Girvan; Chih-Lin Hsieh; Latchezar Dimitrov; Jianfeng Xu; Janet L Stanford; Bo Johanneson; Kerry Deutsch; Laura McIntosh; Elaine A Ostrander; Kathleen E Wiley; Sarah D Isaacs; Patrick C Walsh; Stephen N Thibodeau; Shannon K McDonnell; Scott Hebbring; Daniel J Schaid; Ethan M Lange; Kathleen A Cooney; Teuvo L J Tammela; Johanna Schleutker; Thomas Paiss; Christiane Maier; Henrik Grönberg; Fredrik Wiklund; Monica Emanuelsson; William B Isaacs Journal: Hum Mol Genet Date: 2007-05-03 Impact factor: 6.150