PURPOSE: To evaluate the safety of intravitreal injection of bevacizumab in rabbits using electrophysiological testing and histopathologic analysis. METHODS: New Zealand albino rabbits were injected in one eye with control antibody (n = 2), 0.05 mL of bevacizumab (n = 3), or 0.2 mL of bevacizumab (n = 3). Electroretinograms were obtained 1 week and 4 weeks after injection. Histologic analysis was performed after completion of the electroretinographic studies. RESULTS: No statistical differences were seen in scotopic and photopic a- and b-wave amplitudes between untreated control and bevacizumab-injected eyes. No histopathologic differences were identified between untreated control and bevacizumab-injected eyes. CONCLUSION: Our study did not find evidence of retinal toxicity from a single intravitreal injection of bevacizumab in rabbits.
PURPOSE: To evaluate the safety of intravitreal injection of bevacizumab in rabbits using electrophysiological testing and histopathologic analysis. METHODS: New Zealand albino rabbits were injected in one eye with control antibody (n = 2), 0.05 mL of bevacizumab (n = 3), or 0.2 mL of bevacizumab (n = 3). Electroretinograms were obtained 1 week and 4 weeks after injection. Histologic analysis was performed after completion of the electroretinographic studies. RESULTS: No statistical differences were seen in scotopic and photopic a- and b-wave amplitudes between untreated control and bevacizumab-injected eyes. No histopathologic differences were identified between untreated control and bevacizumab-injected eyes. CONCLUSION: Our study did not find evidence of retinal toxicity from a single intravitreal injection of bevacizumab in rabbits.
Authors: Matthias Lüke; Kai Januschowski; Max Warga; Julia Beutel; Martin Leitritz; Faik Gelisken; Salvatore Grisanti; Toni Schneider; Christoph Lüke; Karl Ulrich Bartz-Schmidt; Peter Szurman Journal: Br J Ophthalmol Date: 2007-03-23 Impact factor: 4.638
Authors: Priscilla K Brastianos; Harry C Brastianos; Wesley Hsu; Daniel M Sciubba; Thomas Kosztowski; Betty M Tyler; Violette Renard Recinos; Peter Burger; Stuart A Grossman Journal: J Neurooncol Date: 2011-07-26 Impact factor: 4.130
Authors: Saloomeh Saati; Rajat N Agrawal; Stan Louie; Gerald J Chader; Mark S Humayun Journal: Graefes Arch Clin Exp Ophthalmol Date: 2009-07-31 Impact factor: 3.117