Literature DB >> 17031255

PGC-1alpha gene and physical activity in type 2 diabetes mellitus.

Paul W Franks1, Ruth J F Loos.   

Abstract

Exercise stimulates PGC-1alpha gene expression and increases V O2max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1alpha mRNA and nucleotide sequence variation at PGC-1alpha associate with lower level of V O2max and increased diabetes risk. Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.

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Year:  2006        PMID： 17031255     DOI： 10.1249/01.jes.0000240021.92254.23

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN： 0091-6331            Impact factor:   6.230


  9 in total

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9.  The Gly482Ser genotype at the PPARGC1A gene and elevated blood pressure: a meta-analysis involving 13,949 individuals.

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  9 in total

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