Literature DB >> 17031197

TGFbeta-mediated signaling and transcriptional regulation in pancreatic development and cancer.

V Ellenrieder1, M E Fernandez Zapico, R Urrutia.   

Abstract

Transforming growth factor-beta (TGFbeta) plays a critical role in pancreatic development and cell proliferation. Binding of TGFbeta to its membrane receptor kinases activates the Smad signaling proteins, allowing them to translocate to the nucleus and participate in the transcriptional control of TGFbeta target genes. In addition, there is an increasing number of cellular mechanisms affecting the final response of a cell to TGFbeta. This includes crosstalk with other signaling pathways and the induction of TGFbeta early response genes, such as the TGFbeta-inducible early response gene (TIEG) family of transcription factors. Like the Smads, TIEGs behave as downstream effector proteins in TGFbeta-mediated pancreatic growth control. The discovery of the Smads and TIEGs has provided new insights into TGFbeta-regulated functions. Their significance in pancreatic development and cancer is discussed in this review.

Entities:  

Year:  2001        PMID： 17031197      PMCID： PMC3733232          DOI： 10.1097/00001574-200109000-00006

Source DB:  PubMed          Journal:  Curr Opin Gastroenterol        ISSN： 0267-1379            Impact factor:   3.287


  52 in total

Review 1.  Intercellular signals regulating pancreas development and function.

Authors:  S K Kim; M Hebrok
Journal:  Genes Dev       Date:  2001-01-15       Impact factor: 11.361

2.  Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription.

Authors:  M E Engel; M A McDonnell; B K Law; H L Moses
Journal:  J Biol Chem       Date:  1999-12-24       Impact factor: 5.157

Review 3.  Smads: transcriptional activators of TGF-beta responses.

Authors:  R Derynck; Y Zhang; X H Feng
Journal:  Cell       Date:  1998-12-11       Impact factor: 41.582

4.  Smad6 inhibits signalling by the TGF-beta superfamily.

Authors:  T Imamura; M Takase; A Nishihara; E Oeda; J Hanai; M Kawabata; K Miyazono
Journal:  Nature       Date:  1997-10-09       Impact factor: 49.962

5.  Use of representational difference analysis to study the effect of TGFB on the expression profile of a pancreatic cancer cell line.

Authors:  M M Geng; V Ellenrieder; C Wallrapp; F Müller-Pillasch; G Sommer; G Adler; T M Gress
Journal:  Genes Chromosomes Cancer       Date:  1999-09       Impact factor: 5.006

6.  Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

Authors:  D R Welch; A Fabra; M Nakajima
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

7.  Role of transforming growth factor-beta signaling in cancer.

Authors:  M P de Caestecker; E Piek; A B Roberts
Journal:  J Natl Cancer Inst       Date:  2000-09-06       Impact factor: 13.506

Review 8.  Tumor suppressor activity of the TGF-beta pathway in human cancers.

Authors:  S D Markowitz; A B Roberts
Journal:  Cytokine Growth Factor Rev       Date:  1996-06       Impact factor: 7.638

Review 9.  TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth.

Authors:  T Cook; R Urrutia
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2000-04       Impact factor: 4.052

10.  TGF-beta plays a key role in morphogenesis of the pancreatic islets of Langerhans by controlling the activity of the matrix metalloproteinase MMP-2.

Authors:  F Miralles; T Battelino; P Czernichow; R Scharfmann
Journal:  J Cell Biol       Date:  1998-11-02       Impact factor: 10.539
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  5 in total

1.  Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammals.

Authors:  Gwen A Lomberk; Issei Imoto; Brian Gebelein; Raul Urrutia; Tiffany A Cook
Journal:  Pancreatology       Date:  2010-03-26       Impact factor: 3.996

Review 2.  TGFbeta-regulated transcriptional mechanisms in cancer.

Authors:  Volker Ellenrieder; Anita Buck; Thomas M Gress
Journal:  Int J Gastrointest Cancer       Date:  2002

Review 3.  Functional role of KLF10 in multiple disease processes.

Authors:  Malayannan Subramaniam; John R Hawse; Nalini M Rajamannan; James N Ingle; Thomas C Spelsberg
Journal:  Biofactors       Date:  2010 Jan-Feb       Impact factor: 6.113

4.  Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling.

Authors:  Mark J Truty; Gwen Lomberk; Martin E Fernandez-Zapico; Raul Urrutia
Journal:  J Biol Chem       Date:  2008-12-15       Impact factor: 5.157

Review 5.  CD36 and CD97 in Pancreatic Cancer versus Other Malignancies.

Authors:  Cristiana Tanase; Ancuta-Augustina Gheorghisan-Galateanu; Ionela Daniela Popescu; Simona Mihai; Elena Codrici; Radu Albulescu; Mihail Eugen Hinescu
Journal:  Int J Mol Sci       Date:  2020-08-06       Impact factor: 5.923
  5 in total

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