OBJECTIVE: To explore a quantitative trait locus (QTL) on human chromosome 1q affecting BMI, adiposity, and fat-free mass phenotypes in the Quebec Family Study cohort. RESEARCH METHODS AND PROCEDURES: Non-parametric sibpair and variance component linkage analyses and family-based association studies were performed with a dense set of chromosome 1q43 microsatellites and single-nucleotide polymorphism markers in 885 adult individuals. RESULTS: Linkage was observed between marker D1S184 and BMI (p = 0.0004) and with body fat mass or percentage body fat (p < or = 0.0003), but no linkage was detected with fat-free mass. Furthermore, significant linkages (p < 0.0001) were achieved with subsamples of sibpairs at both ends of phenotype distributions. Association studies with quantitative transmission disequilibrium tests refined the linkage to a region overlapping the regulator of G-protein signaling 7 (RGS7) gene and extending to immediate upstream gene loci. DISCUSSION: The present study indicates that the QTL on chromosome 1q43 specifically affects total adiposity and provides a genetic mapping framework for the dissection of this adiposity locus.
OBJECTIVE: To explore a quantitative trait locus (QTL) on human chromosome 1q affecting BMI, adiposity, and fat-free mass phenotypes in the Quebec Family Study cohort. RESEARCH METHODS AND PROCEDURES: Non-parametric sibpair and variance component linkage analyses and family-based association studies were performed with a dense set of chromosome 1q43 microsatellites and single-nucleotide polymorphism markers in 885 adult individuals. RESULTS: Linkage was observed between marker D1S184 and BMI (p = 0.0004) and with body fat mass or percentage body fat (p < or = 0.0003), but no linkage was detected with fat-free mass. Furthermore, significant linkages (p < 0.0001) were achieved with subsamples of sibpairs at both ends of phenotype distributions. Association studies with quantitative transmission disequilibrium tests refined the linkage to a region overlapping the regulator of G-protein signaling 7 (RGS7) gene and extending to immediate upstream gene loci. DISCUSSION: The present study indicates that the QTL on chromosome 1q43 specifically affects total adiposity and provides a genetic mapping framework for the dissection of this adiposity locus.
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Authors: Jeffrey L Waugh; Jeremy Celver; Meenakshi Sharma; Robert L Dufresne; Dimitra Terzi; S Craig Risch; William G Fairbrother; Rachael L Neve; John P Kane; Mary J Malloy; Clive R Pullinger; Harvest F Gu; Christos Tsatsanis; Steven P Hamilton; Stephen J Gold; Venetia Zachariou; Abraham Kovoor Journal: PLoS One Date: 2011-11-23 Impact factor: 3.240
Authors: Brahim Aissani; Kui Zhang; Arjen R Mensenkamp; Fred H Menko; Howard W Wiener Journal: Endocr Relat Cancer Date: 2015-06-25 Impact factor: 5.678