| Literature DB >> 17030764 |
E Cubo1, K M Shannon, D Tracy, J A Jaglin, B A Bernard, J Wuu, S E Leurgans.
Abstract
Striatal cholinergic dysfunction may be important in Huntington disease (HD). We studied whether donepezil improves chorea, cognition, and quality of life (QoL) in HD. Thirty patients were randomly assigned to treatment with donepezil or placebo. At the doses studied, donepezil did not improve chorea, cognition, or QoL. Adverse events were similar between both groups. Based on this small sample study, donepezil was not an effective treatment for HD.Entities:
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Year: 2006 PMID： 17030764 DOI： 10.1212/01.wnl.0000238106.10423.00
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910