Literature DB >> 1703076

Ethanol potentiates the GABAA-activated Cl- current in mouse hippocampal and cortical neurons.

L G Aguayo1.   

Abstract

The effects of ethanol (1-80 mM) on GABA-activated Cl- current (IGABA) were studied in cultured mammalian hippocampal and cortical neurons. Patch-clamp recordings revealed that ethanol potentiated the Cl- current in a concentration-dependent manner (1-40 mM) in the majority of the cells studied. No higher degree of potentiation was found by increasing the concentration of ethanol to 80 mM. This study demonstrates that ethanol can potentiate IGABA in mammalian central neurons.

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Year:  1990        PMID： 1703076     DOI： 10.1016/0014-2999(90)90349-b

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  35 in total

1.  GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumption.

Authors:  Aki Takahashi; Carolyn Kwa; Joseph F Debold; Klaus A Miczek
Journal:  Psychopharmacology (Berl)       Date:  2010-06-30       Impact factor: 4.530

Review 2.  Low dose acute alcohol effects on GABA A receptor subtypes.

Authors:  Martin Wallner; H Jacob Hanchar; Richard W Olsen
Journal:  Pharmacol Ther       Date:  2006-07-11       Impact factor: 12.310

Review 3.  Acute alcohol action and desensitization of ligand-gated ion channels.

Authors:  Alex M Dopico; David M Lovinger
Journal:  Pharmacol Rev       Date:  2009-03-06       Impact factor: 25.468

Review 4.  GABA(A) receptors and alcohol.

Authors:  Ingrid A Lobo; R Adron Harris
Journal:  Pharmacol Biochem Behav       Date:  2008-03-14       Impact factor: 3.533

Review 5.  Effects of acute alcohol on excitability in the CNS.

Authors:  Neil L Harrison; Mary Jane Skelly; Emma K Grosserode; Daniel C Lowes; Tamara Zeric; Sara Phister; Michael C Salling
Journal:  Neuropharmacology       Date:  2017-05-04       Impact factor: 5.250

6.  Increasing effect of ethanol on 5-HT3 receptor-mediated 14C-guanidinium influx in N1E-115 neuroblastoma cells.

Authors:  M Barann; K Ruppert; M Göthert; H Bönisch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-08       Impact factor: 3.000

7.  The effects of acute and chronic ethanol exposure on presynaptic and postsynaptic gamma-aminobutyric acid (GABA) neurotransmission in cultured cortical and hippocampal neurons.

Authors:  Rebekah L Fleming; Paul B Manis; A Leslie Morrow
Journal:  Alcohol       Date:  2009-12       Impact factor: 2.405

8.  The interaction of trichloroethanol with murine recombinant 5-HT3 receptors.

Authors:  D L Downie; A G Hope; D Belelli; J J Lambert; J A Peters; K R Bentley; L J Steward; C Y Chen; N M Barnes
Journal:  Br J Pharmacol       Date:  1995-04       Impact factor: 8.739

Review 9.  Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses.

Authors:  Carlos F Burgos; Braulio Muñoz; Leonardo Guzman; Luis G Aguayo
Journal:  Pharmacol Res       Date:  2015-07-06       Impact factor: 7.658

10.  Changes in intrinsic inhibition in isolated hippocampal slices during ethanol withdrawal; lack of correlation with withdrawal hyperexcitability.

Authors:  M A Whittington; H J Little; J D Lambert
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739
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