Literature DB >> 17030496

Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniae.

Helen M Marriott1, Paul G Hellewell, Moira K B Whyte, David H Dockrell.   

Abstract

The pulmonary innate response to low-dose bacterial challenge requires functioning alveolar macrophages (AM) but also subsequent macrophage apoptosis. To address the role of reactive oxygen species (ROS) and nitric oxide (NO) in AM apoptosis, sub-clinical Streptococcus pneumoniae infection was established in gp91(phox-/-) and inducible NO synthase deficient (iNOS(-/-)) mice. Both AM apoptosis and the number of macrophages containing apoptotic bodies are reduced in iNOS(-/-) as compared to control or gp91(phox-/-) mice. iNOS(-/-) mice recruit neutrophils and generate TNF-alpha to compensate for impaired AM competence but ROS deficiency has no apparent effect on AM function in this model.

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Year:  2006        PMID： 17030496     DOI： 10.1016/j.vaccine.2006.09.024

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  11 in total

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Authors:  Claudia N Paiva; Marcelo T Bozza
Journal:  Antioxid Redox Signal       Date:  2013-10-26       Impact factor: 8.401

Review 2.  Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killing.

Authors:  J D Aberdein; J Cole; M A Bewley; H M Marriott; D H Dockrell
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4.  Influenza infection suppresses NADPH oxidase-dependent phagocytic bacterial clearance and enhances susceptibility to secondary methicillin-resistant Staphylococcus aureus infection.

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8.  A cardinal role for cathepsin d in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci.

Authors:  Martin A Bewley; Helen M Marriott; Calogero Tulone; Sheila E Francis; Timothy J Mitchell; Robert C Read; Benny Chain; Guido Kroemer; Moira K B Whyte; David H Dockrell
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9.  Alveolar Macrophage Apoptosis-associated Bacterial Killing Helps Prevent Murine Pneumonia.

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10.  Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease.

Authors:  Antony Payton; Debbie Payne; Limangeni A Mankhambo; Daniel L Banda; C Anthony Hart; William Er Ollier; Enitan D Carrol
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