Literature DB >> 17030084

Information about a form (on the dynamic laws of morphogenesis).

Lev V Beloussov1, Vassily I Grabovsky.   

Abstract

How a developing embryo becomes "informed" about its form?" This problem remains obscure and controversial. We argue that the "information about a form" is distributed throughout three main components: the dynamic laws, the parameters and the initial/boundary conditions. In the absence of a dynamic law two other components are "blind", that is, do not contain any unambiguous information. We present a version of a dynamic law of morphogenesis, based upon the presumption of a feedback between passive and active mechanical stresses. We explore several models of shape formation based upon this law and show that, as depending upon the parameters values, they generate a large set of realistic shapes. Genetic and epigenetic basis of the models parameters is discussed.

Mesh:

Year:  2006        PMID: 17030084     DOI: 10.1016/j.biosystems.2006.09.015

Source DB:  PubMed          Journal:  Biosystems        ISSN: 0303-2647            Impact factor:   1.973


  5 in total

1.  Theoretical study of Beloussov's hyper-restoration hypothesis for mechanical regulation of morphogenesis.

Authors:  Larry A Taber
Journal:  Biomech Model Mechanobiol       Date:  2007-10-02

2.  On the Role of Autonomous Control in Organ Development.

Authors:  Ashok Ramasubramanian
Journal:  J Dyn Syst Meas Control       Date:  2013-08-23       Impact factor: 1.372

Review 3.  Morphogenetic fields in embryogenesis, regeneration, and cancer: non-local control of complex patterning.

Authors:  Michael Levin
Journal:  Biosystems       Date:  2012-04-20       Impact factor: 1.973

Review 4.  Computational models for mechanics of morphogenesis.

Authors:  Matthew A Wyczalkowski; Zi Chen; Benjamen A Filas; Victor D Varner; Larry A Taber
Journal:  Birth Defects Res C Embryo Today       Date:  2012-06

Review 5.  Synthetic living machines: A new window on life.

Authors:  Mo R Ebrahimkhani; Michael Levin
Journal:  iScience       Date:  2021-05-04
  5 in total

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