| Literature DB >> 17029998 |
BaoChang Qi1, Yue Huang, Dominic Rowe, Glenda Halliday.
Abstract
Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.Entities:
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Year: 2006 PMID： 17029998 DOI： 10.1016/j.biocel.2006.08.016
Source DB: PubMed Journal: Int J Biochem Cell Biol ISSN： 1357-2725 Impact factor: 5.085