OBJECTIVE: To determine the effects of interferon-gamma (IFN-gamma) on bone remodeling during orthodontic tooth movement. MATERIALS AND METHODS: Thirty adult male Sprague Dawley rats were randomly categorized into five groups. IFN-gamma was administered in three different doses (0.01, 0.02, and 0.05 microg/20 microL) and the remaining two groups served as control. Mandibular first molars were moved mesially by means of Ni-Ti closed coil springs in all groups. The results were evaluated histomorphometrically, and parameters of trabecular bone volume (BV/TV), trabecular bone number (Tr.N), and trabecular separation (Tr.Sep) were observed at the interradicular bone area of the mandibular first molars. RESULTS: Increases in BV/TV and Tr.N and decreases in Tr.Sep revealed the antiosteoclastic activity of IFN-gamma. CONCLUSION: IFN-gamma administration may be useful clinically for anchorage control.
OBJECTIVE: To determine the effects of interferon-gamma (IFN-gamma) on bone remodeling during orthodontic tooth movement. MATERIALS AND METHODS: Thirty adult male Sprague Dawley rats were randomly categorized into five groups. IFN-gamma was administered in three different doses (0.01, 0.02, and 0.05 microg/20 microL) and the remaining two groups served as control. Mandibular first molars were moved mesially by means of Ni-Ti closed coil springs in all groups. The results were evaluated histomorphometrically, and parameters of trabecular bone volume (BV/TV), trabecular bone number (Tr.N), and trabecular separation (Tr.Sep) were observed at the interradicular bone area of the mandibular first molars. RESULTS: Increases in BV/TV and Tr.N and decreases in Tr.Sep revealed the antiosteoclastic activity of IFN-gamma. CONCLUSION:IFN-gamma administration may be useful clinically for anchorage control.
Authors: Luca Fiorillo; Gabriele Cervino; Alan Scott Herford; Floriana Lauritano; Cesare D'Amico; Roberto Lo Giudice; Luigi Laino; Giuseppe Troiano; Salvatore Crimi; Marco Cicciù Journal: Int J Mol Sci Date: 2018-06-29 Impact factor: 5.923
Authors: Felipe José Fernández-González; Aránzazu Cañigral; Felipe Balbontín-Ayala; José Manuel Gonzalo-Orden; Felix de Carlos; Teresa Cobo; Jose Pedro Fernández-Vázquez; Fernando Sánchez-Lasheras; José Antonio Vega Journal: Dental Press J Orthod Date: 2015-10