Literature DB >> 1702902

Dominant negative regulation of the mouse alpha-fetoprotein gene in adult liver.

J Vacher1, S M Tilghman.   

Abstract

Transcription of the mouse alpha-fetoprotein gene is activated in the developing fetal liver and gut and repressed in both tissues shortly after birth. With germline transformation in mice, a cis-acting element was identified upstream of the transcription initiation site of the alpha-fetoprotein gene that was responsible for repression of the gene in adult liver. This negative element acts as a repressor in a position-dependent manner.

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Year:  1990        PMID： 1702902     DOI： 10.1126/science.1702902

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

1.  The mouse alpha-fetoprotein promoter is repressed in HepG2 hepatoma cells by hepatocyte nuclear factor-3 (FOXA).

Authors:  Mei-Chuan Huang; Kelly Ke Li; Brett T Spear
Journal:  DNA Cell Biol       Date:  2002-08       Impact factor: 3.311

2.  p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding.

Authors:  K C Lee; A J Crowe; M C Barton
Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

3.  S-Phase progression mediates activation of a silenced gene in synthetic nuclei.

Authors:  A J Crowe; J L Piechan; L Sang; M C Barton
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

4.  Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.

Authors:  D Bernier; H Thomassin; D Allard; M Guertin; D Hamel; M Blaquière; M Beauchemin; H LaRue; M Estable-Puig; L Bélanger
Journal:  Mol Cell Biol       Date:  1993-03       Impact factor: 4.272

5.  A promoter-linked coupling region required for stimulation of alpha-fetoprotein transcription by distant enhancers.

Authors:  P Wen; N Crawford; J Locker
Journal:  Nucleic Acids Res       Date:  1993-04-25       Impact factor: 16.971

6.  Individual mouse alpha-fetoprotein enhancer elements exhibit different patterns of tissue-specific and hepatic position-dependent activities.

Authors:  T M Ramesh; A W Ellis; B T Spear
Journal:  Mol Cell Biol       Date:  1995-09       Impact factor: 4.272

7.  Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver.

Authors:  Zhifang Xie; Hai Zhang; Wenwei Tsai; Ye Zhang; Yu Du; Jigen Zhong; Claude Szpirer; Minghua Zhu; Xuetao Cao; Michelle Craig Barton; Michael J Grusby; Weiping J Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-31       Impact factor: 11.205

8.  Analysis of perinatal gene expression: hormone response elements mediate activation of a lacZ reporter gene in liver of transgenic mice.

Authors:  L Montoliu; J A Blendy; T J Cole; G Schütz
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

9.  Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.

Authors:  G L Semenza; S T Koury; M K Nejfelt; J D Gearhart; S E Antonarakis
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

10.  Alpha-fetoprotein: from a diagnostic biomarker to a key role in female fertility.

Authors:  Christelle De Mees; Julie Bakker; Josiane Szpirer; Claude Szpirer
Journal:  Biomark Insights       Date:  2007-02-07
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