Brenna L Anderson1, Lisa A Cosentino, Hyagriv N Simhan, Sharon L Hillier. 1. Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens Research Institute, Magee-Womens Hospital of the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. banderson@wihri.org
Abstract
OBJECTIVE: The objective of this study was to characterize the systemic immune response in women with trichomoniasis in pregnancy as compared with uninfected women. STUDY DESIGN: A nested case control study was performed on 195 serum samples. Serum concentrations of cytokines, chemokines, and C-reactive protein (CRP) were compared between infected and uninfected women. Cytokines and chemokines were measured using a multiplex bead assay. The CRP concentrations were determined using a standard enzyme-linked immunosorbent assay method. RESULTS: The median serum concentration of granulocyte-macrophage colony-stimulating factor (GM-CSF) was significantly higher in the trichomonas-infected group compared with the uninfected group (8.9 pg/mL vs. 5.7 pg/mL; P <0.001). The mean log-transformed CRP values were higher in the infected group compared with the uninfected group (1.66 vs. 1.27; P = 0.03). CONCLUSIONS: The results of this study suggest that trichomoniasis during pregnancy can lead to a systemic immune response in some women as exhibited by elevation in the serum concentrations of both GM-CSF and CRP.
OBJECTIVE: The objective of this study was to characterize the systemic immune response in women with trichomoniasis in pregnancy as compared with uninfected women. STUDY DESIGN: A nested case control study was performed on 195 serum samples. Serum concentrations of cytokines, chemokines, and C-reactive protein (CRP) were compared between infected and uninfected women. Cytokines and chemokines were measured using a multiplex bead assay. The CRP concentrations were determined using a standard enzyme-linked immunosorbent assay method. RESULTS: The median serum concentration of granulocyte-macrophage colony-stimulating factor (GM-CSF) was significantly higher in the trichomonas-infected group compared with the uninfected group (8.9 pg/mL vs. 5.7 pg/mL; P <0.001). The mean log-transformed CRP values were higher in the infected group compared with the uninfected group (1.66 vs. 1.27; P = 0.03). CONCLUSIONS: The results of this study suggest that trichomoniasis during pregnancy can lead to a systemic immune response in some women as exhibited by elevation in the serum concentrations of both GM-CSF and CRP.
Authors: Melissa Milbrandt; Anke C Winter; Remington L Nevin; Ratna Pakpahan; Gary Bradwin; Angelo M De Marzo; Debra J Elliott; Charlotte A Gaydos; William B Isaacs; William G Nelson; Nader Rifai; Lori J Sokoll; Jonathan M Zenilman; Elizabeth A Platz; Siobhan Sutcliffe Journal: Prostate Date: 2017-07-12 Impact factor: 4.104
Authors: María G Ramírez-Ledesma; Yordan J Romero-Contreras; Mayra C Rodríguez; Ruth Reyes-Cortes; Patricia Cuéllar-Mata; Eva E Avila Journal: Parasitol Res Date: 2022-03-08 Impact factor: 2.289