BACKGROUND: Identification of familial, more homogenous characteristics of obsessive-compulsive disorder (OCD) may help to define relevant subtypes and increase the power of genetic and neurobiological studies of OCD. While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions. METHODS: Four hundred eighteen sibling pairs with OCD were evaluated using the Structured Clinical Interview for DSM-IV and the Yale-Brown Obsessive Compulsive Scale (YBOCS) Symptom Checklist and Severity scales. RESULTS: After controlling for sex, age, and age of onset, robust sib-sib intraclass correlations were found for two of the four YBOCS factors: Factor IV (hoarding obsessions and compulsions (p = .001) and Factor I (aggressive, sexual, and religious obsessions, and checking compulsions; p = .002). Smaller, but still significant, familiality was found for Factor III (contamination/cleaning; p = .02) and Factor II (symmetry/ordering/arranging; p = .04). Limiting the sample to female subjects more than doubled the familiality estimates for Factor II (p = .003). Among potentially relevant comorbid conditions for genetic studies, bipolar I/II and major depressive disorder were strongly associated with Factor I (p < .001), whereas ADHD, alcohol dependence, and bulimia were associated with Factor II (p < .01). CONCLUSIONS: Factor-analyzed OCD symptom dimensions in sibling pairs with OCD are familial with some gender-dependence, exhibit relatively specific relationships to comorbid psychiatric disorders and thus may be useful as refined phenotypes for molecular genetic studies of OCD.
BACKGROUND: Identification of familial, more homogenous characteristics of obsessive-compulsive disorder (OCD) may help to define relevant subtypes and increase the power of genetic and neurobiological studies of OCD. While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions. METHODS: Four hundred eighteen sibling pairs with OCD were evaluated using the Structured Clinical Interview for DSM-IV and the Yale-Brown Obsessive Compulsive Scale (YBOCS) Symptom Checklist and Severity scales. RESULTS: After controlling for sex, age, and age of onset, robust sib-sib intraclass correlations were found for two of the four YBOCS factors: Factor IV (hoarding obsessions and compulsions (p = .001) and Factor I (aggressive, sexual, and religious obsessions, and checking compulsions; p = .002). Smaller, but still significant, familiality was found for Factor III (contamination/cleaning; p = .02) and Factor II (symmetry/ordering/arranging; p = .04). Limiting the sample to female subjects more than doubled the familiality estimates for Factor II (p = .003). Among potentially relevant comorbid conditions for genetic studies, bipolar I/II and major depressive disorder were strongly associated with Factor I (p < .001), whereas ADHD, alcohol dependence, and bulimia were associated with Factor II (p < .01). CONCLUSIONS: Factor-analyzed OCD symptom dimensions in sibling pairs with OCD are familial with some gender-dependence, exhibit relatively specific relationships to comorbid psychiatric disorders and thus may be useful as refined phenotypes for molecular genetic studies of OCD.
Authors: David Mataix-Cols; Bjarne Hansen; Manuel Mattheisen; Elinor K Karlsson; Anjené M Addington; Julia Boberg; Diana R Djurfeldt; Matthew Halvorsen; Paul Lichtenstein; Stian Solem; Kerstin Lindblad-Toh; Jan Haavik; Gerd Kvale; Christian Rück; James J Crowley Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2019-08-19 Impact factor: 3.568
Authors: Hilga Katerberg; Kevin L Delucchi; S Evelyn Stewart; Christine Lochner; Damiaan A J P Denys; Denise E Stack; J Michael Andresen; J E Grant; Suck W Kim; Kyle A Williams; Johan A den Boer; Anton J L M van Balkom; Johannes H Smit; Patricia van Oppen; Annemiek Polman; Michael A Jenike; Dan J Stein; Carol A Mathews; Danielle C Cath Journal: Behav Genet Date: 2010-04-02 Impact factor: 2.805
Authors: Dennis L Murphy; Pablo R Moya; Meredith A Fox; Liza M Rubenstein; Jens R Wendland; Kiara R Timpano Journal: Philos Trans R Soc Lond B Biol Sci Date: 2013-02-25 Impact factor: 6.237
Authors: G Nestadt; C Z Di; M A Riddle; M A Grados; B D Greenberg; A J Fyer; J T McCracken; S L Rauch; D L Murphy; S A Rasmussen; B Cullen; A Pinto; J A Knowles; J Piacentini; D L Pauls; O J Bienvenu; Y Wang; K Y Liang; J F Samuels; K Bandeen Roche Journal: Psychol Med Date: 2008-12-02 Impact factor: 7.723
Authors: Jack F Samuels; O Joseph Bienvenu; Anthony Pinto; Dennis L Murphy; John Piacentini; Scott L Rauch; Abby J Fyer; Marco A Grados; Benjamin D Greenberg; James A Knowles; James T McCracken; Bernadette Cullen; Mark A Riddle; Steven A Rasmussen; David L Pauls; Kung-Yee Liang; Rudolf Hoehn-Saric; Ann E Pulver; Gerald Nestadt Journal: Behav Res Ther Date: 2008-06-27