Literature DB >> 17027650

Thrombin induces rapid PAR1-mediated non-classical FGF1 release.

Maria Duarte1, Vihren Kolev, Raffaella Soldi, Alexander Kirov, Irene Graziani, Silvia Marta Oliveira, Doreen Kacer, Robert Friesel, Thomas Maciag, Igor Prudovsky.   

Abstract

Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 17027650      PMCID： PMC1698861          DOI： 10.1016/j.bbrc.2006.09.107

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

Review 1.  The non-classical export routes: FGF1 and IL-1alpha point the way.

Authors:  Igor Prudovsky; Anna Mandinova; Raffaella Soldi; Cinzia Bagala; Irene Graziani; Matteo Landriscina; Francesca Tarantini; Maria Duarte; Stephen Bellum; Holly Doherty; Thomas Maciag
Journal:  J Cell Sci       Date:  2003-12-15       Impact factor: 5.285

2.  Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation.

Authors:  T K Vu; D T Hung; V I Wheaton; S R Coughlin
Journal:  Cell       Date:  1991-03-22       Impact factor: 41.582

3.  Thrombin stimulates c-sis gene expression in microvascular endothelial cells.

Authors:  T O Daniel; V C Gibbs; D F Milfay; M R Garovoy; L T Williams
Journal:  J Biol Chem       Date:  1986-07-25       Impact factor: 5.157

4.  Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells.

Authors:  Huiqing Cao; Nagadhara Dronadula; Gadiparthi N Rao
Journal:  Am J Physiol Cell Physiol       Date:  2005-09-07       Impact factor: 4.249

5.  Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex.

Authors:  P Mignatti; T Morimoto; D B Rifkin
Journal:  J Cell Physiol       Date:  1992-04       Impact factor: 6.384

6.  The inhibition of fibroblast growth factor-2 export by cardenolides implies a novel function for the catalytic subunit of Na+,K+-ATPase.

Authors:  R Z Florkiewicz; J Anchin; A Baird
Journal:  J Biol Chem       Date:  1998-01-02       Impact factor: 5.157

7.  Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells.

Authors:  Bernhard H Rauch; Esther Millette; Richard D Kenagy; Guenter Daum; Alexander W Clowes
Journal:  Circ Res       Date:  2003-12-11       Impact factor: 17.367

8.  Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells.

Authors:  A Jackson; S Friedman; X Zhan; K A Engleka; R Forough; T Maciag
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-15       Impact factor: 11.205

9.  Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro.

Authors:  T K Rosengart; W V Johnson; R Friesel; R Clark; T Maciag
Journal:  Biochem Biophys Res Commun       Date:  1988-04-15       Impact factor: 3.575

10.  Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells.

Authors:  J M Harlan; P J Thompson; R R Ross; D F Bowen-Pope
Journal:  J Cell Biol       Date:  1986-09       Impact factor: 10.539
View more
  10 in total

Review 1.  Secretion without Golgi.

Authors:  Igor Prudovsky; Francesca Tarantini; Matteo Landriscina; David Neivandt; Raffaella Soldi; Aleksandr Kirov; Deena Small; Karuppanan Muthusamy Kathir; Dakshinamurthy Rajalingam; Thallapuranam Krishnaswamy Suresh Kumar
Journal:  J Cell Biochem       Date:  2008-04-01       Impact factor: 4.429

2.  Probing the role of proline -135 on the structure, stability, and cell proliferation activity of human acidic fibroblast growth factor.

Authors:  Julie Eberle Davis; Arwa Alghanmi; Ravi Kumar Gundampati; Srinivas Jayanthi; Ellen Fields; Monica Armstrong; Vanessa Weidling; Varun Shah; Shilpi Agrawal; Bhanu Prasanth Koppolu; David A Zaharoff; Thallapuranam Krishnaswamy Suresh Kumar
Journal:  Arch Biochem Biophys       Date:  2018-07-19       Impact factor: 4.013

3.  Changes in amniotic fluid concentration of thrombin-antithrombin III complexes in patients with preterm labor: evidence of an increased thrombin generation.

Authors:  Offer Erez; Roberto Romer; Edi Vaisbuch; Tinnakorn Chaiworapongsa; Juan Pedro Kusanovic; Shali Mazaki-Tovi; Francesca Gotsch; Ricardo Gomez; Eli Maymon; Percy Pacora; Samuel S Edwin; Chong Jai Kim; Nandor Gabor Than; Pooja Mittal; Lami Yeo; Zhong Dong; Bo Hyun Yoon; Sonia S Hassan; Moshe Mazor
Journal:  J Matern Fetal Neonatal Med       Date:  2009-11

4.  Novel cross-talk between three cardiovascular regulators: thrombin cleavage fragment of Jagged1 induces fibroblast growth factor 1 expression and release.

Authors:  Maria Duarte; Vihren Kolev; Doreen Kacer; Carla Mouta-Bellum; Raffaella Soldi; Irene Graziani; Aleksandr Kirov; Robert Friesel; Lucy Liaw; Deena Small; Joseph Verdi; Thomas Maciag; Igor Prudovsky
Journal:  Mol Biol Cell       Date:  2008-09-10       Impact factor: 4.138

5.  Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas: Prognostic significance.

Authors:  Marta Tiburcio; Sandra M A Costa; Maria DE Fatima Duarte; Fernando C Schmitt; Adhemar Longatto Filho
Journal:  Oncol Lett       Date:  2012-07-17       Impact factor: 2.967

6.  Over-expression of the thrombin receptor (PAR-1) in the placenta in preeclampsia: a mechanism for the intersection of coagulation and inflammation.

Authors:  Offer Erez; Roberto Romero; Sung-Su Kim; Jung-Sun Kim; Yeon Mee Kim; Derek E Wildman; Nandor Gabor Than; Shali Mazaki-Tovi; Francesca Gotsch; Beth Pineles; Juan Pedro Kusanovic; Jimmy Espinoza; Pooja Mittal; Moshe Mazor; Sonia S Hassan; Chong Jai Kim
Journal:  J Matern Fetal Neonatal Med       Date:  2008-06

7.  Transgenic expression of nonclassically secreted FGF suppresses kidney repair.

Authors:  Aleksandr Kirov; Maria Duarte; Justin Guay; Michele Karolak; Cong Yan; Leif Oxburgh; Igor Prudovsky
Journal:  PLoS One       Date:  2012-05-14       Impact factor: 3.240

Review 8.  The characteristics of thrombin in osteoarthritic pathogenesis and treatment.

Authors:  Pei-Yu Chou; Chen-Ming Su; Chun-Yin Huang; Chih-Hsin Tang
Journal:  Biomed Res Int       Date:  2014-09-16       Impact factor: 3.411

9.  Protein-phospholipid interactions in nonclassical protein secretion: problem and methods of study.

Authors:  Igor Prudovsky; Thallapuranam Krishnaswamy Suresh Kumar; Sarah Sterling; David Neivandt
Journal:  Int J Mol Sci       Date:  2013-02-08       Impact factor: 5.923

10.  Nonclassically Secreted Regulators of Angiogenesis.

Authors:  Igor Prudovsky
Journal:  Angiol Open Access       Date:  2013-02-28
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.