Literature DB >> 1702733

(+)-Tubocurarine is a potent inhibitor of cation channels in the vacuolar membrane of Chenopodium rubrum L.

T Weiser1, F W Bentrup.   

Abstract

The effect of the acetylcholine antagonist and channel blocker (+)-tubocurarine on the calcium-dependent slow vacuolar (SV) cation channels in the tonoplast of suspension-cultured cells of Chenopodium rubrum L. was examined using the patch-clamp technique. In whole-vacuolar recordings the drug strongly suppressed the potassium conductance (EC50: 6 microM) and altered the kinetics of channel inactivation. In excised membrane patches (+)-tubocurarine evokes channel-'flickering' without affecting the single-channel conductance (approx. 80 pS).

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Year:  1990        PMID： 1702733     DOI： 10.1016/0014-5793(90)80849-e

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

Review 1.  Green circuits--the potential of plant specific ion channels.

Authors:  R Hedrich; D Becker
Journal:  Plant Mol Biol       Date:  1994-12       Impact factor: 4.076

2.  Pharmacology of the SV channel in the vacuolar membrane of Chenopodium rubrum suspension cells.

Authors:  T Weiser; F W Bentrup
Journal:  J Membr Biol       Date:  1993-10       Impact factor: 1.843

3.  Elicitor-activated phospholipase A(2) generates lysophosphatidylcholines that mobilize the vacuolar H(+) pool for pH signaling via the activation of Na(+)-dependent proton fluxes.

Authors:  Katrin Viehweger; Batsuch Dordschbal; Werner Roos
Journal:  Plant Cell       Date:  2002-07       Impact factor: 11.277

4.  Calmodulin regulates the Ca(2+)-dependent slow-vacuolar ion channel in the tonoplast of Chenopodium rubrum suspension cells.

Authors:  T Weiser; W Blum; F W Bentrup
Journal:  Planta       Date:  1991-10       Impact factor: 4.116
  4 in total

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