Literature DB >> 1702730

Studies on the primary sequence requirements for PKC-alpha, -beta 1 and -gamma peptide substrates.

R M Marais1, O Nguyen, J R Woodgett, P J Parker.   

Abstract

The substrate specificity of purified PKC-alpha, -beta and -gamma has been investigated. A series of synthetic peptides based upon the sequence surrounding serine-7 in glycogen synthase were generated and used to determine the basic residue requirements of these PKC isotypes. While PKC-alpha and -beta are indistinguishable in their phosphorylation of these peptides, PKC-gamma shows a distinct specificity profile for these synthetic substrates.

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Year:  1990        PMID： 1702730     DOI： 10.1016/0014-5793(90)80831-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


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  9 in total

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