Literature DB >> 17026991

mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats.

Joyce Besheer1, Rebekah A Stevenson, Clyde W Hodge.   

Abstract

Recent work has identified a role for metabotropic glutamate receptor subtype 5 (mGlu(5)) in the discriminative stimulus properties of investigator-administered ethanol. The purpose of this study was to determine if mGlu(5) receptors modulate the discriminative stimulus properties of self-administered ethanol. Results show that the mGlu(5) receptor antagonist 6-Methyl-2-(phenylethynyl)pyridine (MPEP; 10 mg/kg) inhibited the discriminative stimulus properties of consumed ethanol during a self-administration test session. Further, 10 mg/kg MPEP increased and 1 mg/kg MPEP decreased the amount of self-administered ethanol required to produce full substitution. These results indicate that mGlu(5) receptors are involved in the expression of the discriminative stimulus properties of self-administered ethanol.

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Year:  2006        PMID： 17026991      PMCID： PMC1676072          DOI： 10.1016/j.ejphar.2006.08.071

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  14 in total

1.  Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties.

Authors:  Kevin D Lominac; Zuzana Kapasova; Reem A Hannun; Cole Patterson; Lawrence D Middaugh; Karen K Szumlinski
Journal:  Drug Alcohol Depend       Date:  2006-05-11       Impact factor: 4.492

2.  The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats.

Authors:  Neil E Paterson; Athina Markou
Journal:  Psychopharmacology (Berl)       Date:  2004-12-24       Impact factor: 4.530

3.  The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats.

Authors:  Jason P Schroeder; David H Overstreet; Clyde W Hodge
Journal:  Psychopharmacology (Berl)       Date:  2005-02-17       Impact factor: 4.530

Review 4.  Discriminative stimulus effects of ethanol: neuropharmacological characterization.

Authors:  W Kostowski; P Bieńkowski
Journal:  Alcohol       Date:  1999-01       Impact factor: 2.405

5.  The discriminative stimulus properties of self-administered ethanol are mediated by GABA(A) and NMDA receptors in rats.

Authors:  C W Hodge; A A Cox; A M Bratt; R Camarini; K Iller; S P Kelley; K K Mehmert; M A Nannini; M F Olive
Journal:  Psychopharmacology (Berl)       Date:  2001-02       Impact factor: 4.530

6.  Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes.

Authors:  K Minami; R W Gereau; M Minami; S F Heinemann; R A Harris
Journal:  Mol Pharmacol       Date:  1998-01       Impact factor: 4.436

7.  Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.

Authors:  Jun Kitano; Kouji Kimura; Yoshimitsu Yamazaki; Takeshi Soda; Ryuichi Shigemoto; Yoshiaki Nakajima; Shigetada Nakanishi
Journal:  J Neurosci       Date:  2002-02-15       Impact factor: 6.167

8.  Discriminative stimulus effects of self-administered ethanol.

Authors:  K L Shelton; M J Macenski
Journal:  Behav Pharmacol       Date:  1998-07       Impact factor: 2.293

9.  mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior.

Authors:  Pia Bäckström; Daniel Bachteler; Sabrina Koch; Petri Hyytiä; Rainer Spanagel
Journal:  Neuropsychopharmacology       Date:  2004-05       Impact factor: 7.853

10.  Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol.

Authors:  Joyce Besheer; Clyde W Hodge
Journal:  Neuropsychopharmacology       Date:  2005-04       Impact factor: 7.853
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  32 in total

1.  mGlu receptors and drug addiction.

Authors:  Richard M Cleva; M Foster Olive
Journal:  Wiley Interdiscip Rev Membr Transp Signal       Date:  2012-01-20

Review 2.  Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.

Authors:  M Foster Olive
Journal:  Eur J Pharmacol       Date:  2010-04-02       Impact factor: 4.432

Review 3.  Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse.

Authors:  George R Breese; Rajita Sinha; Markus Heilig
Journal:  Pharmacol Ther       Date:  2010-10-15       Impact factor: 12.310

4.  The effects of repeated corticosterone exposure on the interoceptive effects of alcohol in rats.

Authors:  Joyce Besheer; Kristen R Fisher; Julie J M Grondin; Reginald Cannady; Clyde W Hodge
Journal:  Psychopharmacology (Berl)       Date:  2011-10-21       Impact factor: 4.530

Review 5.  Metabotropic glutamate receptor ligands as potential therapeutics for addiction.

Authors:  M Foster Olive
Journal:  Curr Drug Abuse Rev       Date:  2009-01

6.  Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082.

Authors:  Michael C Salling; Sara Faccidomo; Clyde W Hodge
Journal:  Pharmacol Biochem Behav       Date:  2008-06-14       Impact factor: 3.533

Review 7.  Metabotropic and ionotropic glutamate receptors as potential targets for the treatment of alcohol use disorder.

Authors:  Sunil Goodwani; Hannah Saternos; Fawaz Alasmari; Youssef Sari
Journal:  Neurosci Biobehav Rev       Date:  2017-02-24       Impact factor: 8.989

Review 8.  Cross-Species Translational Findings in the Discriminative Stimulus Effects of Ethanol.

Authors:  Daicia C Allen; Matthew M Ford; Kathleen A Grant
Journal:  Curr Top Behav Neurosci       Date:  2018

9.  Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats.

Authors:  J Besheer; S Faccidomo; J J M Grondin; C W Hodge
Journal:  Alcohol       Date:  2008-02       Impact factor: 2.405

10.  Ethanol-induced alterations of c-Fos immunoreactivity in specific limbic brain regions following ethanol discrimination training.

Authors:  Joyce Besheer; Jason P Schroeder; Rebekah A Stevenson; Clyde W Hodge
Journal:  Brain Res       Date:  2008-07-26       Impact factor: 3.252
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