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Literature DB >> 17026580

A human lymph node in vitro--challenges and progress.

Christoph Giese¹, Christian D Demmler, Richard Ammer, Stefan Hartmann, Annika Lubitz, Lilja Miller, Riccarda Müller, Uwe Marx.

Abstract

Extracorporeal human lymphatic organs are expected to be excellent tools in the study of human molecular and cellular bases of the immunologic balance and tissue harmony. A rational approach and process to design a device and a procedure to recreate the human lymph node environment in vitro is described with emphasis on T-cell activation. Based on this approach, a bioreactor and a process supporting self-assembly of human lymphatic tissues due to proper emulation of human architecture and homeostasis could be developed.

Entities: Species

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Year: 2006 PMID： 17026580 DOI： 10.1111/j.1525-1594.2006.00303.x

Source DB: PubMed Journal: Artif Organs ISSN： 0160-564X Impact factor: 3.094

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Cited

31 in total

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Journal: Ann N Y Acad Sci Date: 2008 Impact factor: 5.691

Review 2. Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.

Authors: Uwe Marx; Tommy B Andersson; Anthony Bahinski; Mario Beilmann; Sonja Beken; Flemming R Cassee; Murat Cirit; Mardas Daneshian; Susan Fitzpatrick; Olivier Frey; Claudia Gaertner; Christoph Giese; Linda Griffith; Thomas Hartung; Minne B Heringa; Julia Hoeng; Wim H de Jong; Hajime Kojima; Jochen Kuehnl; Marcel Leist; Andreas Luch; Ilka Maschmeyer; Dmitry Sakharov; Adrienne J A M Sips; Thomas Steger-Hartmann; Danilo A Tagle; Alexander Tonevitsky; Tewes Tralau; Sergej Tsyb; Anja van de Stolpe; Rob Vandebriel; Paul Vulto; Jufeng Wang; Joachim Wiest; Marleen Rodenburg; Adrian Roth
Journal: ALTEX Date: 2016-05-15 Impact factor: 6.043

3. Modeling human adaptive immune responses with tonsil organoids.

Authors: Lisa E Wagar; Ameen Salahudeen; Christian M Constantz; Ben S Wendel; Michael M Lyons; Vamsee Mallajosyula; Lauren P Jatt; Julia Z Adamska; Lisa K Blum; Neha Gupta; Katherine J L Jackson; Fan Yang; Katharina Röltgen; Krishna M Roskin; Kelly M Blaine; Kara D Meister; Iram N Ahmad; Mario Cortese; Emery G Dora; Sean N Tucker; Anne I Sperling; Aarti Jain; D Huw Davies; Philip L Felgner; Gregory B Hammer; Peter S Kim; William H Robinson; Scott D Boyd; Calvin J Kuo; Mark M Davis
Journal: Nat Med Date: 2021-01-11 Impact factor: 53.440

A human lymph node in vitro--challenges and progress.

Review 1. Lymphatic tissue engineering: progress and prospects.

Review 2. Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing.

3. Modeling human adaptive immune responses with tonsil organoids.

4. Spatially resolved microfluidic stimulation of lymphoid tissue ex vivo.

5. Species neutral correlates of immunogenicity for vaccines and protein therapeutics: fact or science fiction.

6. Long-term immunologically competent human peripheral lymphoid tissue cultures in a 3D bioreactor.

Review 7. Cell and tissue engineering in lymph nodes for cancer immunotherapy.

Review 8. Tissue engineering and regeneration of lymphatic structures.

9. Assuring consumer safety without animals: Applications for tissue engineering.

10. Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro.