Literature DB >> 1702603

Physiologic properties of myelin proteins revealed by their expression in nonglial cells.

D R Colman1, S M Staugaitis, D D'Urso, M P Sinoway, B Allinquant, L Bernier, A Mentaberry, J G Stempak, P J Brophy.   

Abstract

The transfection paradigm described herein can be used to investigate the functional properties of individual nervous system proteins in ways that have not been explored before. In particular, observations on the "structural" proteins of myelin are being made that have already yielded certain unique insights into the physiologic properties of these polypeptides. The ease with which site-directed mutagenesis procedures can be applied to these systems should eventually enable us to define with great precision the "functional domains" within each myelin protein.

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Year:  1990        PMID: 1702603     DOI: 10.1111/j.1749-6632.1990.tb42403.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN: 0077-8923            Impact factor:   5.691


  4 in total

1.  The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal.

Authors:  Graham S T Smith; Lauren V Seymour; Joan M Boggs; George Harauz
Journal:  Biochem Biophys Res Commun       Date:  2012-05-16       Impact factor: 3.575

Review 2.  Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms.

Authors:  George Harauz; Joan M Boggs
Journal:  J Neurochem       Date:  2013-03-06       Impact factor: 5.372

3.  Proteolipid/DM-20 proteins bearing the paralytic tremor mutation in peripheral nerves and transfected Cos-7 cells.

Authors:  M Tosic; A Gow; M Dolivo; K Domanska-Janik; R A Lazzarini; J M Matthieu
Journal:  Neurochem Res       Date:  1996-04       Impact factor: 3.996

4.  Nucleus-localized 21.5-kDa myelin basic protein promotes oligodendrocyte proliferation and enhances neurite outgrowth in coculture, unlike the plasma membrane-associated 18.5-kDa isoform.

Authors:  Graham S T Smith; Bożena Samborska; Steven P Hawley; Jordan M Klaiman; Todd E Gillis; Nina Jones; Joan M Boggs; George Harauz
Journal:  J Neurosci Res       Date:  2012-11-27       Impact factor: 4.164

  4 in total

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