Literature DB >> 1702564

Thiacetazone: in vitro activity against Mycobacterium avium and M. tuberculosis.

L B Heifets1, P J Lindholm-Levy, M Flory.   

Abstract

Bacteriostatic and bactericidal activity of thiacetazone was determined for 68 M. avium clinical isolates and 14 wild drug-susceptible M. tuberculosis strains. The drug had equally low bactericidal activity against both mycobacterial species. The inhibitory activity against most of the M. avium strains was greater than it was against M. tuberculosis. The broth determined MICs for 65 of 68 M. avium strains were between 0.02 and 0.15 micrograms/ml, while the MICs for M. tuberculosis ranged from 0.08 to 1.2 micrograms/ml.

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Year:  1990        PMID: 1702564     DOI: 10.1016/0041-3879(90)90043-8

Source DB:  PubMed          Journal:  Tubercle        ISSN: 0041-3879


  5 in total

Review 1.  World Health Organization group 5 drugs for the treatment of drug-resistant tuberculosis: unclear efficacy or untapped potential?

Authors:  Kelly E Dooley; Ekwaro A Obuku; Nadza Durakovic; Vera Belitsky; Carole Mitnick; Eric L Nuermberger
Journal:  J Infect Dis       Date:  2012-07-17       Impact factor: 5.226

Review 2.  Beige mouse model for Mycobacterium avium complex disease.

Authors:  P R Gangadharam
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191

3.  Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.

Authors:  Luiz E Bermudez; Robert Reynolds; Peter Kolonoski; Pricilla Aralar; Clark B Inderlied; Lowell S Young
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

4.  EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.

Authors:  Lynn G Dover; Anuradha Alahari; Paul Gratraud; Jessica M Gomes; Veemal Bhowruth; Robert C Reynolds; Gurdyal S Besra; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2007-01-12       Impact factor: 5.191

Review 5.  Tuberculosis chemotherapy: current drug delivery approaches.

Authors:  Lisa Claire du Toit; Viness Pillay; Michael Paul Danckwerts
Journal:  Respir Res       Date:  2006-09-19
  5 in total

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