BACKGROUND: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations. METHODS: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry. RESULTS: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed. Post hoc analyses revealed that schizophrenia patients (n = 15) had significantly larger lateral ventricles as compared to controls. Duration and dose of antipsychotics correlated negatively with global gray matter volume in minimally medicated patients (n = 18). CONCLUSION: Findings of white matter changes and enlarged lateral ventricles already at illness onset in young schizophrenia spectrum patients, suggests aberrant neurodevelopmental processes in the pathogenesis of these disorders. Gray matter volume changes, however, appear not to be a key feature in early onset first-episode psychosis.
BACKGROUND: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations. METHODS: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry. RESULTS: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed. Post hoc analyses revealed that schizophreniapatients (n = 15) had significantly larger lateral ventricles as compared to controls. Duration and dose of antipsychotics correlated negatively with global gray matter volume in minimally medicated patients (n = 18). CONCLUSION: Findings of white matter changes and enlarged lateral ventricles already at illness onset in young schizophrenia spectrum patients, suggests aberrant neurodevelopmental processes in the pathogenesis of these disorders. Gray matter volume changes, however, appear not to be a key feature in early onset first-episode psychosis.
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Authors: L Friedman; R L Findling; J T Kenny; T P Swales; T A Stuve; J A Jesberger; J S Lewin; S C Schulz Journal: Biol Psychiatry Date: 1999-07-01 Impact factor: 13.382
Authors: L Marsh; D Harris; K O Lim; M Beal; A L Hoff; K Minn; J G Csernansky; S DeMent; W O Faustman; E V Sullivan; A Pfefferbaum Journal: Arch Gen Psychiatry Date: 1997-12
Authors: J L Rapoport; J N Giedd; J Blumenthal; S Hamburger; N Jeffries; T Fernandez; R Nicolson; J Bedwell; M Lenane; A Zijdenbos; T Paus; A Evans Journal: Arch Gen Psychiatry Date: 1999-07
Authors: Josefina Castro-Fornieles; Nuria Bargalló; Anna Calvo; Celso Arango; Immaculada Baeza; Ana Gonzalez-Pinto; Mara Parellada; Montserrat Graell; Carmen Moreno; Soraya Otero; Joost Janssen; Marta Rapado-Castro; Elena de la Serna Journal: Eur Child Adolesc Psychiatry Date: 2017-07-13 Impact factor: 4.785
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Authors: Anne Katrine Pagsberg; Pia Jeppesen; Dea Gowers Klauber; Karsten Gjessing Jensen; Ditte Rudå; Marie Stentebjerg-Olesen; Peter Jantzen; Simone Rasmussen; Eva Ann-Sofie Saldeen; Maj-Britt Glenn Lauritsen; Niels Bilenberg; Anne Dorte Stenstrøm; Jesper Pedersen; Louise Nyvang; Sarah Madsen; Marlene B Lauritsen; Ditte Lammers Vernal; Per Hove Thomsen; Jakob Paludan; Thomas M Werge; Kristian Winge; Klaus Juul; Christian Gluud; Maria Skoog; Jørn Wetterslev; Jens Richardt M Jepsen; Christoph U Correll; Anders Fink-Jensen; Birgitte Fagerlund Journal: BMC Psychiatry Date: 2014-07-11 Impact factor: 3.630
Authors: Tiril P Gurholt; Vera Lonning; Stener Nerland; Kjetil N Jørgensen; Unn K Haukvik; Clara Alloza; Celso Arango; Claudia Barth; Carrie E Bearden; Michael Berk; Hannes Bohman; Orwa Dandash; Covadonga M Díaz-Caneja; Carl T Edbom; Theo G M van Erp; Anne-Kathrin J Fett; Sophia Frangou; Benjamin I Goldstein; Anahit Grigorian; Neda Jahanshad; Anthony C James; Joost Janssen; Cecilie Johannessen; Katherine H Karlsgodt; Matthew J Kempton; Peter Kochunov; Lydia Krabbendam; Marinos Kyriakopoulos; Mathias Lundberg; Bradley J MacIntosh; Bjørn Rishovd Rund; Runar E Smelror; Alysha Sultan; Christian K Tamnes; Sophia I Thomopoulos; Ariana Vajdi; Kirsten Wedervang-Resell; Anne M Myhre; Ole A Andreassen; Paul M Thompson; Ingrid Agartz Journal: Hum Brain Mapp Date: 2020-10-05 Impact factor: 5.399