Intracellular regulatory mechanisms in pancreatic acinar cellular function.

The intracellular mechanisms regulating pancreatic acinar cell function are more complex than previously realized. This is probably due in part to the need to match the biosynthetic and secretory functions of the cells. Much information is available on how secretagogue receptors acutely couple through heterotrimeric G proteins to increase intracellular messengers, particularly cytoplasmic free Ca(2+), although details are still being worked out. Less is known about how Ca(2+) signals to induce fusion of zymogen granules with the apical plasma membrane. Investigation has focused on the proteins of the zymogen granule membrane, and several novel proteins have recently been identified. In addition, understanding of the three MAP kinase cascades, the mTOR-p70S6 kinase pathway, and the focal adhesion kinase pathway in acinar cells is increasing. The functions of these pathways in acini have been linked to mitogenesis, protein synthesis, and regulation of the cytoskeleton.