Drug-induced liver disease.

This year's review has been divided into five sections: The first describes the natural history of drug-induced liver disease, the second discusses the issue of placebo-related increases in liver-associated enzymes, the third describes agents newly reported to cause hepatic injury, the fourth discusses new reports of hepatic injury from established drugs, and the final section reviews the burgeoning field of hepatoprotection with clinical and experimental examples of agents used in the prevention and treatment of drug-induced liver disease, with acetaminophen as the major example.