BACKGROUND: The hypothesis that alterations in energy metabolism predict body fat gain is controversial. OBJECTIVE: The aim of this study was to determine which components of energy metabolism were most important in predicting fat gain in children aged 10.8 +/- 0.6 y. DESIGN: A 2-y longitudinal study to examine whether components of energy metabolism are predictors of body fat gain was conducted in 114 preadolescent African American and white children aged 9-11 y by measuring total daily energy expenditure on the basis of doubly labeled water (DLW), resting metabolic rate, the thermic effect of food, energy expended in physical activity, and substrate oxidation after a meal. The primary endpoint was the 2-y change in percentage body fat (%BF). RESULTS: Individual variables of energy metabolism predicted up to 7% of the variance in changes in %BF over the 2-y interval in the whole group. Predictors of change in body fatness tended to be sex and race specific. Protein oxidation during a test meal explained a significant portion of the variance in change in %BF in the overall group and in nearly all of the subgroups. Multivariate prediction models accounted for 10-41% of the variance in change in %BF. Tanner stage at 2-y follow-up was highly predictive of change in body fatness and improved the overall prediction, accounting for 24-62% of the variance in change in %BF in those groups in which Tanner entered the model. CONCLUSION: This study provides evidence that total daily energy expenditure, resting metabolic rate, substrate oxidation, and total energy intake are predictors of gain in body fatness during late childhood in boys and girls.
BACKGROUND: The hypothesis that alterations in energy metabolism predict body fat gain is controversial. OBJECTIVE: The aim of this study was to determine which components of energy metabolism were most important in predicting fat gain in children aged 10.8 +/- 0.6 y. DESIGN: A 2-y longitudinal study to examine whether components of energy metabolism are predictors of body fat gain was conducted in 114 preadolescent African American and white children aged 9-11 y by measuring total daily energy expenditure on the basis of doubly labeled water (DLW), resting metabolic rate, the thermic effect of food, energy expended in physical activity, and substrate oxidation after a meal. The primary endpoint was the 2-y change in percentage body fat (%BF). RESULTS: Individual variables of energy metabolism predicted up to 7% of the variance in changes in %BF over the 2-y interval in the whole group. Predictors of change in body fatness tended to be sex and race specific. Protein oxidation during a test meal explained a significant portion of the variance in change in %BF in the overall group and in nearly all of the subgroups. Multivariate prediction models accounted for 10-41% of the variance in change in %BF. Tanner stage at 2-y follow-up was highly predictive of change in body fatness and improved the overall prediction, accounting for 24-62% of the variance in change in %BF in those groups in which Tanner entered the model. CONCLUSION: This study provides evidence that total daily energy expenditure, resting metabolic rate, substrate oxidation, and total energy intake are predictors of gain in body fatness during late childhood in boys and girls.
Authors: S R J Zinkel; R I Berkowitz; A J Stunkard; V A Stallings; M Faith; D Thomas; D A Schoeller Journal: Pediatr Obes Date: 2016-02-22 Impact factor: 4.000
Authors: Kelvin H M Kwok; Mikael Rydén; Daniel P Andersson; Gallic Beauchef; Christelle Guere; Katell Vie; Otto Bergman; Veroniqa Lundbäck; Peter Arner; Ingrid Dahlman Journal: Int J Obes (Lond) Date: 2019-06-04 Impact factor: 5.095
Authors: Desiree C Wilks; Stephen J Sharp; Ulf Ekelund; Simon G Thompson; Adrian P Mander; Rebecca M Turner; Susan A Jebb; Anna Karin Lindroos Journal: PLoS One Date: 2011-02-23 Impact factor: 3.240
Authors: Simon Thompson; Ulf Ekelund; Susan Jebb; Anna Karin Lindroos; Adrian Mander; Stephen Sharp; Rebecca Turner; Désirée Wilks Journal: Int J Epidemiol Date: 2010-12-23 Impact factor: 7.196
Authors: P J Collings; K Wijndaele; K Corder; K Westgate; C L Ridgway; S J Sharp; A J Atkin; A M Stephen; D Bamber; I Goodyer; S Brage; U Ekelund Journal: Pediatr Obes Date: 2015-04-27 Impact factor: 4.000