Literature DB >> 1702303

Use of the calcium agonist BAY K 8644 for in vitro diagnosis of susceptibility to malignant hyperthermia.

P J Adnet1, R M Krivosic-Horber, G Haudecoeur, M M Adamantidis, G H Reyford, M Imbenotte, C Cordonnier.   

Abstract

We have studied the effects of the calcium agonist BAY K 8644 on the in vitro halothane test in 10 malignant hyperthermia-susceptible (MHS), 12 MH "equivocal" to halothane (MHEh), 30 MH non-susceptible (MHN) and 10 control patients. BAY K 8644 potentiated the halothane-induced contracture in muscle strips from both MHS and MHEh patients. The drug produced a more obvious difference in contracture responses between the MHEh group compared with the MHN and control groups.

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Year:  1990        PMID: 1702303     DOI: 10.1093/bja/65.6.791

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN: 0007-0912            Impact factor:   9.166


  1 in total

1.  Effect of cocaine on the contracture response to 1% halothane in patients undergoing diagnostic muscle biopsy for malignant hyperthermia.

Authors:  N Sato; J M Brum; H Mitsumoto; G E DeBoer
Journal:  Can J Anaesth       Date:  1995-02       Impact factor: 5.063

  1 in total

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