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Literature DB >> 17022968

Baclofen-induced suppression of alcohol deprivation effect in Sardinian alcohol-preferring (sP) rats exposed to different alcohol concentrations.

Giancarlo Colombo¹, Salvatore Serra, Giovanni Vacca, Mauro A M Carai, Gian Luigi Gessa.

Abstract

This study investigated the effect of the gamma-aminobutyric acid(B) (GABA(B)) receptor agonist, baclofen, on alcohol deprivation effect (the transient increase in alcohol intake occurring after a period of alcohol abstinence) in Sardinian alcohol-preferring (sP) rats exposed to 4 bottles containing water and 10%, 20%, and 30% (v/v) alcohol, respectively. Acute administration of baclofen (1 mg/kg, i.p.) suppressed both aspects of alcohol deprivation effect: the extra-intake of alcohol and the selection of the highest concentrated alcohol solution. These results suggest that the GABA(B) receptor is part of the neural substrate mediating alcohol deprivation in sP rats.

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Year: 2006 PMID： 17022968 DOI： 10.1016/j.ejphar.2006.08.052

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

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