Literature DB >> 17022653

Proteomics analysis reveals insight into the mechanism of H-Ras-mediated transformation.

Bao-Feng Jin1, Kun He, Hong-Xia Wang, Bing Bai, Tao Zhou, Hui-Yan Li, Jiang-Hong Man, Bing-Yu Liu, Wei-Li Gong, Jie Wang, Ai-Ling Li, Xue-Min Zhang.   

Abstract

We implemented a proteomics approach to the systematical analysis of the alterations in the proteome of NIH3T3 cells transformed by oncogenic H-RasV12. Forty-four proteins associated with Ras-mediated transformation have been identified, and 28 proteins were not previously reported. RT-PCR analysis showed that approximately 44% of target proteins identified showed concomitant changes in mRNA abundance. A principal finding was the up-regulation of gankyrin, which was the first evidence to show that gankyrin pathway was implicated in Ras-activated transformation.

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Year:  2006        PMID： 17022653     DOI： 10.1021/pr060283f

Source DB:  PubMed          Journal:  J Proteome Res        ISSN： 1535-3893            Impact factor:   4.466


  5 in total

1.  Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.

Authors:  Jiang-Hong Man; Bing Liang; Yue-Xi Gu; Tao Zhou; Ai-Ling Li; Tao Li; Bao-Feng Jin; Bing Bai; Hai-Ying Zhang; Wei-Na Zhang; Wei-Hua Li; Wei-Li Gong; Hui-Yan Li; Xue-Min Zhang
Journal:  J Clin Invest       Date:  2010-07-12       Impact factor: 14.808

2.  Quantitative expression of Ikaros, IRF4, and PSMD10 proteins predicts survival in VRD-treated patients with multiple myeloma.

Authors:  Irena Misiewicz-Krzeminska; Cristina de Ramón; Luis A Corchete; Patryk Krzeminski; Elizabeta A Rojas; Isabel Isidro; Ramón García-Sanz; Joaquín Martínez-López; Albert Oriol; Joan Bladé; Juan-José Lahuerta; Jesús San Miguel; Laura Rosiñol; María-Victoria Mateos; Norma C Gutiérrez
Journal:  Blood Adv       Date:  2020-12-08

3.  Proteome analysis for downstream targets of oncogenic KRAS--the potential participation of CLIC4 in carcinogenesis in the lung.

Authors:  Koji Okudela; Akira Katayama; Tetsukan Woo; Hideaki Mitsui; Takehisa Suzuki; Yoko Tateishi; Shigeaki Umeda; Michihiko Tajiri; Munetaka Masuda; Noriyuki Nagahara; Hitoshi Kitamura; Kenichi Ohashi
Journal:  PLoS One       Date:  2014-02-04       Impact factor: 3.240

4.  Label-free quantitative phosphoproteomics with novel pairwise abundance normalization reveals synergistic RAS and CIP2A signaling.

Authors:  Otto Kauko; Teemu Daniel Laajala; Mikael Jumppanen; Petteri Hintsanen; Veronika Suni; Pekka Haapaniemi; Garry Corthals; Tero Aittokallio; Jukka Westermarck; Susumu Y Imanishi
Journal:  Sci Rep       Date:  2015-08-17       Impact factor: 4.379

5.  Gankyrin gene deletion followed by proteomic analysis: insight into the roles of Gankyrin in tumorigenesis and metastasis.

Authors:  Xue Luo; Liang Chen; Jiang Dai; Yanfei Gao; Hongli Wang; Na Wang; Yongqiang Zhao; Feng Liu; Zhihong Sang; Jie Wang; Weihua Li; Kun He; Baofeng Jin; Jianghong Man; Wei Zhang; Qing Xia
Journal:  BMC Med Genomics       Date:  2012-08-22       Impact factor: 3.063
  5 in total

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