| Literature DB >> 17022003 |
Berthold Büchele1, Waltraud Zugmaier, Aidee Estrada, Felicitas Genze, Tatiana Syrovets, Christian Paetz, Bernd Schneider, Thomas Simmet.
Abstract
3Alpha-acetyl-11-keto-alpha-boswellic acid (3alpha-acetoxy-11-oxo-olean-12-en-24-oic acid, 1) was synthesized by a radical-type reaction using bromine and 3alpha-acetyl-alpha-boswellic acid isolated from the oleo-gum-resin of Boswellia carterii. 1D and 2D NMR (COSY, HMBC, ROESY) at 500 MHz were used for shift assignments and structure verification. The compound investigated is present in a herbal preparation extracted from Boswellia serrata oleo-gum-resin, it inhibits the growth of chemotherapy-resistant human PC-3 prostate cancer cells in vitro and induces apoptosis as shown by activation of caspase 3 and the induction of DNA fragmentation. In addition, compound 1 is active IN VIVO as shown by inhibition of proliferation and induction of apoptosis in PC-3 prostate cancer cells xenotransplanted onto the chick chorioallantoic membrane.Entities:
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Year: 2006 PMID： 17022003 DOI： 10.1055/s-2006-951680
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352