Literature DB >> 1702066

Identification and cDNA sequence of delta-preprotachykinin, a fourth splicing variant of the rat substance P precursor.

A J Harmar1, V Hyde, K Chapman.   

Abstract

The neuropeptides substance P and neurokinin A are synthesised from a family of precursor polypeptides encoded by the preprotachykinin A (PPT) gene. In addition to a mRNA (beta-PPT) containing all 7 exons of the gene, alternatively spliced mRNAs lacking either exon 4 (gamma-PPT) or exon 6 (alpha-PPT) have been identified. We have determined the sequences of cDNA clones encoding four variants of PPT mRNA from rat dorsal root ganglion (DRG), including a novel mRNA species (delta-PPT) in which both exons 4 and 6 are absent. The sequence of delta-PPT predicts the existence of a novel tachykinin precursor polypeptide.

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Year:  1990        PMID： 1702066     DOI： 10.1016/0014-5793(90)81429-r

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  6 in total

1.  Novel cell lines for the analysis of preprotachykinin A gene expression identify a repressor domain 3' of the major transcriptional start site.

Authors:  C E Fiskerstrand; P Newey; B Ebrahimi; L Gerrard; P Harrison; G P McGregor; J P Quinn
Journal:  Biochem J       Date:  1999-08-01       Impact factor: 3.857

2.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-05-11       Impact factor: 16.971

Review 3.  Substance P receptor antagonists in psychiatry: rationale for development and therapeutic potential.

Authors:  Inga Herpfer; Klaus Lieb
Journal:  CNS Drugs       Date:  2005       Impact factor: 5.749

4.  Effects of endogenous substance P expression on degranulation in RBL-2H3 cells.

Authors:  Hua Hu; Ruxin Zhang; Xiaoyun Fang; Min Yu; Shaoqing Yu; Jie Zhang; Hong Wang
Journal:  Inflamm Res       Date:  2010-12-29       Impact factor: 4.575

5.  Gangliocytes in neuroblastic tumors express alarin, a novel peptide derived by differential splicing of the galanin-like peptide gene.

Authors:  Radmila Santic; Katrin Fenninger; Kerstin Graf; Rainer Schneider; Cornelia Hauser-Kronberger; Freimut H Schilling; Per Kogner; Manfred Ratschek; Neil Jones; Wolfgang Sperl; Barbara Kofler
Journal:  J Mol Neurosci       Date:  2006       Impact factor: 3.444

6.  Quantification of substance p mRNA in human immune cells by real-time reverse transcriptase PCR assay.

Authors:  Jian-Ping Lai; Steven D Douglas; Farida Shaheen; David E Pleasure; Wen-Zhe Ho
Journal:  Clin Diagn Lab Immunol       Date:  2002-01
  6 in total

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