OBJECTIVE: Linkage analysis using 22 Canadian pedigrees identified a promising schizophrenia candidate region on 1q23 with a maximum 2-point HLOD under a recessive model of 5.8 [Brzustowicz et al. 2000]. In the current study, we revisited this data set using a Bayesian linkage analysis technique, namely the posterior probability of linkage (PPL). METHODS: The PPL has been developed as an alternative to traditional linkage analysis. It differs from both LOD scores and 'non-parametric' methods in that it directly measures the probability of linkage given the data, and incorporates prior genomic information. RESULTS: As expected, PPL results for 1q23 supported the previously observed linkage, with an estimated multipoint PPL of 99.7%. However, the PPL supported two further results: a second peak on chromosome 1 at 1p13 with a multipoint with PPL of 70% and a chromosome 17 marker (D17S784 at 17q25) with a multipoint PPL of 44%. CONCLUSIONS: The PPL-based analysis presented has the advantage over other likelihood-based linkage methods in that it avoids maximization and produces a less complex view of the strength of evidence for linkage.
OBJECTIVE: Linkage analysis using 22 Canadian pedigrees identified a promising schizophrenia candidate region on 1q23 with a maximum 2-point HLOD under a recessive model of 5.8 [Brzustowicz et al. 2000]. In the current study, we revisited this data set using a Bayesian linkage analysis technique, namely the posterior probability of linkage (PPL). METHODS: The PPL has been developed as an alternative to traditional linkage analysis. It differs from both LOD scores and 'non-parametric' methods in that it directly measures the probability of linkage given the data, and incorporates prior genomic information. RESULTS: As expected, PPL results for 1q23 supported the previously observed linkage, with an estimated multipoint PPL of 99.7%. However, the PPL supported two further results: a second peak on chromosome 1 at 1p13 with a multipoint with PPL of 70% and a chromosome 17 marker (D17S784 at 17q25) with a multipoint PPL of 44%. CONCLUSIONS: The PPL-based analysis presented has the advantage over other likelihood-based linkage methods in that it avoids maximization and produces a less complex view of the strength of evidence for linkage.
Authors: L Guan; Q Wang; L Wang; B Wu; Y Chen; F Liu; F Ye; T Zhang; K Li; B Yan; C Lu; L Su; G Jin; H Wang; H Tian; L Wang; Z Chen; Y Wang; J Chen; Y Yuan; W Cong; J Zheng; J Wang; X Xu; H Liu; W Xiao; C Han; Y Zhang; F Jia; X Qiao; D Zhang; M Zhang; H Ma Journal: Mol Psychiatry Date: 2016-01-05 Impact factor: 15.992
Authors: Naomi S Wratten; Holly Memoli; Yungui Huang; Anna M Dulencin; Paul G Matteson; Michelle A Cornacchia; Marco A Azaro; Jaime Messenger; Jared E Hayter; Anne S Bassett; Steven Buyske; James H Millonig; Veronica J Vieland; Linda M Brzustowicz Journal: Am J Psychiatry Date: 2009-03-02 Impact factor: 18.112
Authors: William Manley; Michael P Moreau; Marco Azaro; Stephen K Siecinski; Gillian Davis; Steven Buyske; Veronica Vieland; Anne S Bassett; Linda Brzustowicz Journal: PLoS One Date: 2018-03-12 Impact factor: 3.240