Literature DB >> 17018399

Detection of risk-identifying chromosomal abnormalities and genomic profiling by multiplex ligation-dependent probe amplification in chronic lymphocytic leukemia.

Arjan Buijs, Pieter Jaap Krijtenburg, Ellen Meijer.   

Abstract

We performed genomic profiling using multiplex ligation-dependent probe amplification (MLPA) in 54 cases with suspected or advanced chronic lymphocytic leukemia (CLL). MLPA detected abnormalities when the percentage of mutated cells was greater than approximately 35%. Loss of 9p21 CDNK2A/B was revealed. MLPA is an economically attractive, powerful tool in trial-based, centralized risk-assessment for CLL.

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Year:  2006        PMID： 17018399

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  4 in total

Review 1.  Genetic alterations in chronic lymphocytic leukaemia.

Authors:  Llorenç Coll-Mulet; Joan Gil
Journal:  Clin Transl Oncol       Date:  2009-04       Impact factor: 3.405

2.  Genomic alterations in chronic lymphocytic leukemia and their correlation with clinico-hematological parameters and disease progression.

Authors:  Vishrut K Srinivasan; Shano Naseem; Neelam Varma; Deepesh P Lad; Pankaj Malhotra
Journal:  Blood Res       Date:  2020-09-30

3.  Multiplex ligation-dependent probe amplification versus multiprobe fluorescence in situ hybridization to detect genomic aberrations in chronic lymphocytic leukemia: a tertiary center experience.

Authors:  Eiman A Al Zaabi; Louis A Fernandez; Irene A Sadek; D Christie Riddell; Wenda L Greer
Journal:  J Mol Diagn       Date:  2010-01-21       Impact factor: 5.568

Review 4.  Use of the MLPA assay in the molecular diagnosis of gene copy number alterations in human genetic diseases.

Authors:  Liborio Stuppia; Ivana Antonucci; Giandomenico Palka; Valentina Gatta
Journal:  Int J Mol Sci       Date:  2012-03-08       Impact factor: 6.208
  4 in total

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