| Literature DB >> 17018274 |
Alberto Mantovani1, Frances Balkwill.
Abstract
A connection between the genetic events that lead to tumor formation and the signaling pathways of the innate immune response has been established. In this issue, Chien et al. (2006) show that the RalB GTPase regulates the IKK family member TBK1, providing an unexpected link between the signaling pathways that promote inflammation and cancer. In tumor cells the RalB/TBK1 pathway inhibits apoptosis and in nontumorigenic cells it stimulates an innate immune response.Entities:
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Year: 2006 PMID： 17018274 DOI： 10.1016/j.cell.2006.09.019
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582