Sodium channels and pain therapy.

Researchers have characterized changes in the nervous system that occur in response to tissue injury in order to identify possible targets for novel therapeutic interventions for the treatment of pain. That blockers of voltage-gated sodium channels (VGSCs) are clinically effective for the treatment of pain associated with certain types of tissue injury suggests that these channels constitute such a target. Furthermore, there are changes in biophysical properties, expression, and/or distribution of VGSCs in subpopulations of primary afferent and central nervous system neurons in response to injury that are consistent with a role for VGSCs in the generation and maintenance of pain. Injury-induced changes in four unique VGSCs have been described. However, each of these channels appears to contribute to pain associated with different forms of injury in different ways.