BACKGROUND: Pain perception ratings in irritable bowel syndrome (IBS) patients suggest that they present either hypoalgesia or hyperalgesia. However, little is known about the physiologic responses these patients present to a somatic painful stimulus. GOALS: The main goal of this project was to study autonomic nervous system responses and the cardiac response to experimental pain in IBS patients. STUDY: This was addressed by exposing 27 women, 14 IBS, and 13 healthy controls (HCs), to a cold water (7 degrees C) immersion test of the forefoot for 2 minutes. Pain perception, galvanic skin responses (GSR), and heart rate (HR) were monitored during and after the immersion. RESULTS: For comparable pain perception, a significant group difference (P<0.02) in the cardiac response was observed during the immersion where the peak rise in HR was much higher for HCs, reaching 22%, whereas it only reached 8% for IBS patients. Moreover, HR variability analysis demonstrated that IBS and HCs had opposite autonomic cardiac reactivity to pain, where IBS had increased parasympathetic/decreased sympathetic reactivity. CONCLUSIONS: For comparable pain perception, IBS subject demonstrated different autonomic nervous system response to pain, which supports the view of autonomic dysregulation in IBS.
BACKGROUND:Pain perception ratings in irritable bowel syndrome (IBS) patients suggest that they present either hypoalgesia or hyperalgesia. However, little is known about the physiologic responses these patients present to a somatic painful stimulus. GOALS: The main goal of this project was to study autonomic nervous system responses and the cardiac response to experimental pain in IBSpatients. STUDY: This was addressed by exposing 27 women, 14 IBS, and 13 healthy controls (HCs), to a cold water (7 degrees C) immersion test of the forefoot for 2 minutes. Pain perception, galvanic skin responses (GSR), and heart rate (HR) were monitored during and after the immersion. RESULTS: For comparable pain perception, a significant group difference (P<0.02) in the cardiac response was observed during the immersion where the peak rise in HR was much higher for HCs, reaching 22%, whereas it only reached 8% for IBSpatients. Moreover, HR variability analysis demonstrated that IBS and HCs had opposite autonomic cardiac reactivity to pain, where IBS had increased parasympathetic/decreased sympathetic reactivity. CONCLUSIONS: For comparable pain perception, IBS subject demonstrated different autonomic nervous system response to pain, which supports the view of autonomic dysregulation in IBS.
Authors: P Cheng; W Shih; M Alberto; A P Presson; A Licudine; E A Mayer; B D Naliboff; L Chang Journal: Neurogastroenterol Motil Date: 2013-07-03 Impact factor: 3.598
Authors: Taylor D Yeater; David J Clark; Lorraine Hoyos; Pedro A Valdes-Hernandez; Julio A Peraza; Kyle D Allen; Yenisel Cruz-Almeida Journal: Chronic Stress (Thousand Oaks) Date: 2021-07-07