UNLABELLED: Our objective was to determine whether human prostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64Cu PET). METHODS: Athymic mice bearing human prostate cancer xenografts were subjected to 64Cu PET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of human copper transporter 1 expression in the tumor tissues. RESULTS: Human prostate cancer xenografts expressing high levels of human copper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gram of tissue: 3.6 +/- 1.3 and 0.6 +/- 0.3, respectively; P = 0.004), at 24 h after injection. CONCLUSION: The data from this study suggested that locally recurrent prostate cancer might be localized with 64Cu PET using 64CuCl2 as a probe.
UNLABELLED: Our objective was to determine whether humanprostate cancer xenografts in mice can be localized by PET using 64CuCl2 as a probe (64CuPET). METHODS: Athymic mice bearing humanprostate cancer xenografts were subjected to 64CuPET, followed by quantitative analysis of the tracer concentrations and immunohistochemistry study of humancopper transporter 1 expression in the tumor tissues. RESULTS:Humanprostate cancer xenografts expressing high levels of humancopper transporter 1 were well visualized on the PET images obtained 24 h after injection but not on the images obtained 1 h after injection. PET quantitative analysis demonstrated a high concentration of 64CuCl2 in the tumors in comparison to that in the left shoulder regions (percentage injected dose per gram of tissue: 3.6 +/- 1.3 and 0.6 +/- 0.3, respectively; P = 0.004), at 24 h after injection. CONCLUSION: The data from this study suggested that locally recurrent prostate cancer might be localized with 64CuPET using 64CuCl2 as a probe.
Authors: Subha Bakthavatsalam; Mark L Sleeper; Azim Dharani; Daniel J George; Tian Zhang; Katherine J Franz Journal: Angew Chem Int Ed Engl Date: 2018-08-29 Impact factor: 15.336
Authors: Erica M Andreozzi; Julia Baguña Torres; Kavitha Sunassee; Joel Dunn; Simon Walker-Samuel; Istvan Szanda; Philip J Blower Journal: Metallomics Date: 2017-11-15 Impact factor: 4.526
Authors: Kaijun Zhang; Mohan R Aruva; Nylla Shanthly; Christopher A Cardi; Satish Rattan; Chirag Patel; Christopher Kim; Peter A McCue; Eric Wickstrom; Mathew L Thakur Journal: J Nucl Med Date: 2007-12-12 Impact factor: 10.057