Literature DB >> 17015489

Mechanisms for cellular cholesterol transport: defects and human disease.

Elina Ikonen1.   

Abstract

This review summarizes the mechanisms of cellular cholesterol transport and monogenic human diseases caused by defects in intracellular cholesterol processing. In addition, selected mouse models of disturbed cholesterol trafficking are discussed. Current pharmacological strategies to prevent atherosclerosis are largely based on altering cellular cholesterol balance and are introduced in this context. Finally, because of the organizing potential of cholesterol in membranes, disturbances in cellular cholesterol transport have implications for a wide variety of human diseases, of which selected examples are given.

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Year:  2006        PMID： 17015489     DOI： 10.1152/physrev.00022.2005

Source DB:  PubMed          Journal:  Physiol Rev        ISSN： 0031-9333            Impact factor:   37.312


  66 in total

1.  Hypercholesterolemia and ApoE deficiency result in severe infection with Lyme disease and relapsing-fever Borrelia.

Authors:  Alvaro Toledo; Javier D Monzón; James L Coleman; Juan C Garcia-Monco; Jorge L Benach
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

Review 2.  Regulation of cholesterol homeostasis.

Authors:  Leigh Goedeke; Carlos Fernández-Hernando
Journal:  Cell Mol Life Sci       Date:  2011-10-19       Impact factor: 9.261

Review 3.  Hedgehog signaling and steroidogenesis.

Authors:  Isabella Finco; Christopher R LaPensee; Kenneth T Krill; Gary D Hammer
Journal:  Annu Rev Physiol       Date:  2015       Impact factor: 19.318

Review 4.  Derangements of intravascular remodeling of lipoproteins in type 2 diabetes mellitus: consequences for atherosclerosis development.

Authors:  Geesje M Dallinga-Thie; Robin P F Dullaart; Arie van Tol
Journal:  Curr Diab Rep       Date:  2008-02       Impact factor: 4.810

5.  Core hydrophobicity tuning of a self-assembled particle results in efficient lipid reduction and favorable organ distribution.

Authors:  Bhabatosh Banik; Ru Wen; Sean Marrache; Anil Kumar; Nagesh Kolishetti; Elizabeth W Howerth; Shanta Dhar
Journal:  Nanoscale       Date:  2017-12-21       Impact factor: 7.790

6.  Targeted disruption of steroidogenic acute regulatory protein D4 leads to modest weight reduction and minor alterations in lipid metabolism.

Authors:  Joshua J Riegelhaupt; Marc P Waase; Jeanne Garbarino; Daniel E Cruz; Jan L Breslow
Journal:  J Lipid Res       Date:  2009-11-17       Impact factor: 5.922

Review 7.  Androgen synthesis in adrenarche.

Authors:  Walter L Miller
Journal:  Rev Endocr Metab Disord       Date:  2009-03       Impact factor: 6.514

8.  Cholesterol induces specific spatial and orientational order in cholesterol/phospholipid membranes.

Authors:  Hector Martinez-Seara; Tomasz Róg; Mikko Karttunen; Ilpo Vattulainen; Ramon Reigada
Journal:  PLoS One       Date:  2010-06-17       Impact factor: 3.240

9.  Multivesicular body formation requires OSBP-related proteins and cholesterol.

Authors:  Hiroyuki Kobuna; Takao Inoue; Machiko Shibata; Keiko Gengyo-Ando; Akitsugu Yamamoto; Shohei Mitani; Hiroyuki Arai
Journal:  PLoS Genet       Date:  2010-08-05       Impact factor: 5.917

10.  Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.

Authors:  Timothy A Schulz; Mal-Gi Choi; Sumana Raychaudhuri; Jason A Mears; Rodolfo Ghirlando; Jenny E Hinshaw; William A Prinz
Journal:  J Cell Biol       Date:  2009-12-14       Impact factor: 10.539
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