Literature DB >> 1701488

Clinical significance of antibodies to a 68 kDa U1RNP polypeptide in connective tissue disease.

N McHugh1, I James, P Maddison.   

Abstract

In a series of 163 patients with systemic lupus erythematosus (SLE) and/or systemic sclerosis and/or mixed connective tissue disease (MCTD), the presence of antibodies to a 68 kDa U1RNP associated polypeptide was more predictive for SLE (88%) than for MCTD (38-68%) using 3 different sets of proposed criteria for the latter condition. In all but one case studied serially the immunoblotting profile remained constant. In SLE recognition of the 68 kDa polypeptide identified a subset with increased vasoreactivity with Raynaud's phenomenon (96%, p less than 0.001) and swollen fingers (68%, p less than 0.001) whereas recognition of a 47 kDa La (SSB) polypeptide was associated with photosensitivity (72%, p less than 0.02), less renal involvement (p less than 0.05) and an older age of disease onset (46.6 years +/- 18.3 SD, p less than 0.002).

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Year:  1990        PMID： 1701488

Source DB:  PubMed          Journal:  J Rheumatol        ISSN： 0315-162X            Impact factor:   4.666


  10 in total

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7.  IgG and IgM anti-snRNP reactivity in sequentially obtained serum samples from patients with connective tissue diseases.

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Review 8.  Widespread vasculopathy with hemolytic uremic syndrome, perimyocarditis and cystic pancreatitis in a young woman with mixed connective tissue disease. Case report and review of the literature.

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9.  Autoantibodies in juvenile-onset myositis: Their diagnostic value and associated clinical phenotype in a large UK cohort.

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Review 10.  Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity.

Authors:  Sonya J Wolf; Shannon N Estadt; Johann E Gudjonsson; J Michelle Kahlenberg
Journal:  Front Immunol       Date:  2018-10-23       Impact factor: 7.561
  10 in total

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