Literature DB >> 17014260

Microinfusions of neurotensin antagonist SR 48692 within the nucleus accumbens core impair spatial learning in rats.

Giovanni Tirado-Santiago1, Gabriel Lázaro-Muñoz, Viviana Rodríguez-González, Carmen S Maldonado-Vlaar.   

Abstract

The involvement of neurotensin (NT) within the nucleus accumbens core (NAC) in behavior has been sparsely investigated. Moreover, little is known of what role NT within the ventral striatum has on spatial learning. The present study investigated whether NT receptors in the NAC are implicated in learning of spatial information. Male Long-Evans rats were trained on a food search spatial learning task. Rats were microinfused with either NT antagonist SR 48692 (50 nM/0.5 =L) or saline in the NAC before each training session. Rats treated with SR 48692 made more reference and working memory errors during the acquisition of spatial learning than did rats infused with saline. These results suggest that NT receptors contribute to NAC-mediated spatial learning.

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Year:  2006        PMID： 17014260     DOI： 10.1037/0735-7044.120.5.1093

Source DB:  PubMed          Journal:  Behav Neurosci        ISSN： 0735-7044            Impact factor:   1.912


  10 in total

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Journal:  Cereb Cortex       Date:  2014-11-18       Impact factor: 5.357

2.  Neurotensinergic augmentation of glutamate release at the perforant path-granule cell synapse in rat dentate gyrus: Roles of L-Type Ca²⁺ channels, calmodulin and myosin light-chain kinase.

Authors:  Haopeng Zhang; Hailong Dong; Saobo Lei
Journal:  Neuropharmacology       Date:  2015-04-02       Impact factor: 5.250

3.  Effects of neurotensin-2 receptor deletion on sensorimotor gating and locomotor activity.

Authors:  David Feifel; Zhen Pang; Zheng Pang; Paul D Shilling; Gilia Melendez; Rudy Schreiber; Donald Button
Journal:  Behav Brain Res       Date:  2010-04-21       Impact factor: 3.332

4.  Neurotensin and neurotensin receptor 1 mRNA expression in song-control regions changes during development in male zebra finches.

Authors:  Devin P Merullo; Chinweike N Asogwa; Miguel Sanchez-Valpuesta; Shin Hayase; Bikash R Pattnaik; Kazuhiro Wada; Lauren V Riters
Journal:  Dev Neurobiol       Date:  2018-03-30       Impact factor: 3.964

5.  Song in an Affiliative Context Relates to the Neural Expression of Dopamine- and Neurotensin-Related Genes in Male European Starlings.

Authors:  Devin P Merullo; Caroline S Angyal; Sharon A Stevenson; Lauren V Riters
Journal:  Brain Behav Evol       Date:  2016-09-10       Impact factor: 1.808

6.  Neurotensin inversely modulates maternal aggression.

Authors:  S C Gammie; K L D'Anna; H Gerstein; S A Stevenson
Journal:  Neuroscience       Date:  2008-12-07       Impact factor: 3.590

7.  Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model.

Authors:  Zhaoyang Xiao; Nicholas I Cilz; Lalitha Kurada; Binqi Hu; Chuanxiu Yang; Etsuko Wada; Colin K Combs; James E Porter; Florian Lesage; Saobo Lei
Journal:  J Neurosci       Date:  2014-05-14       Impact factor: 6.167

8.  6-Hydroxydopamine-Induced Dopamine Reductions in the Nucleus Accumbens, but not the Medial Prefrontal Cortex, Impair Cincinnati Water Maze Egocentric and Morris Water Maze Allocentric Navigation in Male Sprague-Dawley Rats.

Authors:  Amanda A Braun; Robyn M Amos-Kroohs; Arnold Gutierrez; Kerstin H Lundgren; Kim B Seroogy; Charles V Vorhees; Michael T Williams
Journal:  Neurotox Res       Date:  2016-03-22       Impact factor: 3.911

9.  Systemic administration of the neurotensin NTS₁-receptor agonist PD149163 improves performance on a memory task in naturally deficient male brown Norway rats.

Authors:  Ashley A Keiser; Katelin S Matazel; Melissa K Esser; David Feifel; Adam J Prus
Journal:  Exp Clin Psychopharmacol       Date:  2014-09-15       Impact factor: 3.157

10.  Neurotensin receptor 1 gene (NTSR1) polymorphism is associated with working memory.

Authors:  Jin Li; Chuansheng Chen; Chunhui Chen; Qinghua He; He Li; Jun Li; Robert K Moyzis; Gui Xue; Qi Dong
Journal:  PLoS One       Date:  2011-03-04       Impact factor: 3.240
  10 in total

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