Literature DB >> 1701402

Blockage of AMV reverse transcriptase by antisense oligodeoxynucleotides.

N Loreau1, C Boiziau, P Verspieren, D Shire, J J Toulmé.   

Abstract

Synthetic oligodeoxynucleotides, either unmodified or linked to an intercalating agent, have been used to prevent cDNA elongation by the AMV reverse transcriptase. Oligonucleotide/RNA hybrids specifically arrest primer extension. The blockage involves the degradation of the RNA part bound to the antisense oligonucleotide by the RNase-H activity associated with the retroviral polymerase.

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Year:  1990        PMID： 1701402     DOI： 10.1016/0014-5793(90)81327-k

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  4 in total

1.  The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions.

Authors:  E Brossalina; E Pascolo; J J Toulmé
Journal:  Nucleic Acids Res       Date:  1993-12-11       Impact factor: 16.971

2.  In vitro effect of antisense oligonucleotides on human immunodeficiency virus type 1 reverse transcription.

Authors:  B Bordier; C Hélène; P J Barr; S Litvak; L Sarih-Cottin
Journal:  Nucleic Acids Res       Date:  1992-11-25       Impact factor: 16.971

3.  Mechanisms of the inhibition of reverse transcription by antisense oligonucleotides.

Authors:  C Boiziau; N T Thuong; J J Toulmé
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205

4.  A complex genetic switch involving overlapping divergent promoters and DNA looping regulates expression of conjugation genes of a gram-positive plasmid.

Authors:  Gayetri Ramachandran; Praveen K Singh; Juan Roman Luque-Ortega; Luis Yuste; Carlos Alfonso; Fernando Rojo; Ling J Wu; Wilfried J J Meijer
Journal:  PLoS Genet       Date:  2014-10-23       Impact factor: 5.917
  4 in total

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